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NCT00638521 · ClinicalTrials.gov registry record
Immune-cell Membrane Trafficking
A clinical trial of Severe Trauma, sponsored by University of Washington.
- Completed
- Registry status
- 213
- Enrollment target
- 1
- Study location
NCT00638521 is a study of Severe Trauma that has completed, run by University of Washington. The registered enrollment target is 213 participants. The trial reports 1 study location across 1 state.
The verdict
NCT00638521, a study of Severe Trauma, has completed, sponsored by University of Washington.
- COMPLETED
- Registry status
- 213 participants
- Enrollment target
- 1
- Study location
Study Summary
Organ failure following trauma is a leading cause of morbidity and mortality. It appears that the development of organ failure is a direct result of an altered immune response. This altered response results in the production of circulating factors in the blood that causes direct injury to the injured patients' organs. The mechanism in which this altered immune response occurs is unknown. Based on work we have performed in our laboratory, we believe that this response is initiated on the cell membrane of particular immune cells known as macrophages. Although the cell membrane may appear uniform, it is not. The membrane is composed of specific segments that allow proteins to associate with each other forming receptors that are required for immune cell activation. These specific membrane components are composed of various lipids and cholesterol, and have been termed lipid rafts. Based on our laboratory work it appears that these lipid rafts can be altered following injury. In particular both the lipid and protein content within these raft segments may be altered allowing immune cells to become active leading to the production of factors that directly injure normal cells and organs. Thus, we plan to examine if these laboratory findings can be seen in patients suffering from trauma who develop clinical organ failure at Harborview Medical Center. If this is accomplished, this data will lead to the development of both prognostic and therapeutic interventions for the optimal care of injured patient
Conditions Studied
Study Locations (1)
Washington
- Harborview Medical Center - Seattle
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 213 participants |
| Start Date | 2008-06 |
| Est. Completion | 2013-06 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00638521
The ClinicalTrials.gov registry entry for NCT00638521 describes a study currently listed as completed, categorized as an unspecified phase. The registered enrollment target is 213 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Washington, which has 1,048 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Severe Trauma appearing as the primary indexed condition, and to 0 interventions.
NCT00638521 reports 1 study location spanning 1 distinct geographic area - top geographies include Washington.
Frequently Asked Questions
What is clinical trial NCT00638521 about?
NCT00638521 is a clinical study titled "Immune-cell Membrane Trafficking". Organ failure following trauma is a leading cause of morbidity and mortality. It appears that the development of organ failure is a direct result of an altered immune response. This altered response results in the production of circulating factors in the blood that causes direct injury to the injure...
What is the current status of trial NCT00638521?
This trial is currently completed. The enrollment target is 213 participants. The study started on 2008-06. Estimated completion is 2013-06.
What conditions does trial NCT00638521 study?
This clinical trial studies the following conditions: Severe Trauma.
Who is sponsoring clinical trial NCT00638521?
This trial is sponsored by University of Washington, which has 1,048 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00638521 being conducted?
This trial has 1 study location across Washington. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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