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NCT00633763 · ClinicalTrials.gov registry record
PET-CT Scan Method to Monitor Pancreatic B-Cell Loss in Diabetes Mellitus
A clinical trial, sponsored by University of California, Irvine.
- Completed
- Registry status
- 30
- Enrollment target
NCT00633763 is a clinical trial that has completed, run by University of California, Irvine. The registered enrollment target is 30 participants.
The verdict
NCT00633763 has completed, sponsored by University of California, Irvine.
- COMPLETED
- Registry status
- 30 participants
- Enrollment target
Study Summary
The pancreas is an organ that plays major roles in the digestion of food. A part of the pancreas called islet beta-cells produces insulin, which regulates the amount of glucose (a sugar) present in the blood at all times. Type-1 Diabetes Mellitus (T1DM), an autoimmune disorder characterized by destruction of pancreatic islet beta-cells (the cells that produce insulin), affects at least a million individuals in the US alone. In T1DM, a type of white blood cells called T lymphocytes attacks and destroys the pancreatic islet beta-cells, leading to a loss of insulin, an increase in blood glucose, and a dependence on insulin injections for survival. Despite rigorous control of blood sugar, the majority of diabetic patients develop serious complications including retinopathy, nephropathy, neuropathy, microangiopathy and strokes. Non-invasive methods to monitor pancreatic beta-cell loss associated with type-1 diabetes mellitus (T1DM) could improve early diagnosis, provide tools to measure responsiveness to new therapies, and evaluate the efficiency of pancreatic transplantation and graft survival. Our goal is to develop a non-invasive PET-CT imaging method based on binding of a molecule (18F-fallypride) for tracking beta-cell loss during the progression of T1DM. In preliminary studies we demonstrated specific binding of 18F-fallypride to D2 receptors in rat pancreatic sections and we demonstrated that the loss of pancreatic beta cells in streptozotocin-treated rats was associated with a corresponding decrease in 18F-fallypride binding to pancreatic sections. A preliminary 18F-fallypride PET-CT study done by a collaborator in Ohio on a healthy volunteer, revealed 18F-fallypride-uptake by the pancreas that was distinguishable from surrounding tissues. Aim-1 of our project will measure the variability of 18F-fallypride PET-scanning of the pancreas in six healthy volunteers scanned twice with an interval of 4-6 weeks. In Aim-2 of our project, we will compare fallypride PET-C
Interventions
- DRUG 18F-fallypride
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 30 participants |
| Start Date | 2008-02 |
| Est. Completion | 2008-07 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00633763
The ClinicalTrials.gov registry entry for NCT00633763 describes a study currently listed as completed, categorized as an unspecified phase. The registered enrollment target is 30 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of California, Irvine, which has 368 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which 18F-fallypride is the first listed.
NCT00633763 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT00633763 about?
NCT00633763 is a clinical study titled "PET-CT Scan Method to Monitor Pancreatic B-Cell Loss in Diabetes Mellitus". The pancreas is an organ that plays major roles in the digestion of food. A part of the pancreas called islet beta-cells produces insulin, which regulates the amount of glucose (a sugar) present in the blood at all times. Type-1 Diabetes Mellitus (T1DM), an autoimmune disorder characterized by destr...
What is the current status of trial NCT00633763?
This trial is currently completed. The enrollment target is 30 participants. The study started on 2008-02. Estimated completion is 2008-07.
What interventions are being tested in trial NCT00633763?
The interventions under investigation include: 18F-fallypride (DRUG).
Who is sponsoring clinical trial NCT00633763?
This trial is sponsored by University of California, Irvine, which has 368 total clinical trials registered on ClinicalTrials.gov.
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