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NCT00614458 · ClinicalTrials.gov registry record · Phase 2
MK-0518 Intensification And HDAC Inhibition In Depletion Of Resting CD4+ T Cell HIV Infection
A Phase 2 study, sponsored by University of North Carolina, Chapel Hill.
- Terminated
- Registry status
- Phase 2
- Development phase
- 6
- Enrollment target
NCT00614458: Clinical Trial Phase 2 study, sponsored by University of North Carolina, Chapel Hill.
NCT00614458 is a Phase 2 study that was terminated before completion, run by University of North Carolina, Chapel Hill. The registered enrollment target is 6 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (95% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00614458, a Phase 2 study, was terminated before completion, sponsored by University of North Carolina, Chapel Hill.
- TERMINATED
- Registry status
- Phase 2
- Development phase
- 6 participants
- Enrollment target
Study Summary
The purpose of this research study is to see if HIV that persists despite current antiviral therapy can be targeted by new treatments. We will see if adding Raltegravir (MK-0518) and Valproic acid (VPA) to current ART can decrease the amount of latent HIV.
Primary Outcome
A change in infected cells from prior to the initiation of VPA and MK0518 to after 20 weeks of treatment.
Interventions
- DRUG Raltegravir; valproic acid
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 6 participants |
| Start Date | 2007-04 |
| Est. Completion | 2008-09 |
| Phase | Phase 2 |
Why NCT00614458 stopped before completion
NCT00614458 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 6 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (95% lower).
The record links to 0 conditions, and to 1 intervention - of which Raltegravir; valproic acid is the first listed.
NCT00614458 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00614458 about?
NCT00614458 is a clinical study titled "MK-0518 Intensification And HDAC Inhibition In Depletion Of Resting CD4+ T Cell HIV Infection". The purpose of this research study is to see if HIV that persists despite current antiviral therapy can be targeted by new treatments. We will see if adding Raltegravir (MK-0518) and Valproic acid (VPA) to current ART can decrease the amount of latent HIV.
What is the current status of trial NCT00614458?
This trial is currently terminated. It is a Phase 2 study. The enrollment target is 6 participants. The study started on 2007-04. Estimated completion is 2008-09.
What interventions are being tested in trial NCT00614458?
The interventions under investigation include: Raltegravir; valproic acid (DRUG).
Who is sponsoring clinical trial NCT00614458?
This trial is sponsored by University of North Carolina, Chapel Hill, which has 1,109 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00614458's enrollment target sits among peer trials
6 1996th of 2000 higher than 1 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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