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NCT00579683 · ClinicalTrials.gov registry record
Registry for Patients With Acquired Resistance to Small Molecule Kinase Inhibitors in Non-Small-Cell Lung Cancer
A clinical trial, sponsored by Memorial Sloan Kettering Cancer Center.
- Completed
- Registry status
- 228
- Enrollment target
NCT00579683: Completed study, sponsored by Memorial Sloan Kettering Cancer Center.
NCT00579683 is a clinical trial that has completed, run by Memorial Sloan Kettering Cancer Center. The registered enrollment target is 228 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00579683 has completed, sponsored by Memorial Sloan Kettering Cancer Center.
- COMPLETED
- Registry status
- 228 participants
- Enrollment target
Study Summary
The purpose of this study is to try to learn more about how small molecule kinase inhibitors work in treating lung cancer. Some early studies have shown that gefitinib, erlotinib and similar drugs are more likely to work if a particular DNA change (also known as a mutation) is found in a protein that is important in lung cancer. This protein is called the epidermal growth factor receptor (EGFR). Since small molecule kinase inhibitors sometimes stop working, we would like to examine your tumor to learn why these medicines are not working as well. Your tumor will be examined for a variety of things including changes in the DNA of the EGFR. We will also sequence parts of the genes for HER2, HER3, HER4, and KRAS, other proteins thought to be important in lung cancer.
Interventions
- OTHER Tumor core biopsy for RNA isolation
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 228 participants |
| Start Date | 2004-08 |
| Est. Completion | 2016-02 |
What the finished NCT00579683 record still lists
NCT00579683 is an observational study that tracks outcomes without assigning an intervention. The registered 228 participants enrollment target is mid-sized for trials with a published cap.
The record links to 0 conditions, and to 1 intervention - of which Tumor core biopsy for RNA isolation is the first listed.
NCT00579683 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00579683 about?
NCT00579683 is a clinical study titled "Registry for Patients With Acquired Resistance to Small Molecule Kinase Inhibitors in Non-Small-Cell Lung Cancer". The purpose of this study is to try to learn more about how small molecule kinase inhibitors work in treating lung cancer. Some early studies have shown that gefitinib, erlotinib and similar drugs are more likely to work if a particular DNA change (also known as a mutation) is found in a protein tha...
What is the current status of trial NCT00579683?
This trial is currently completed. The enrollment target is 228 participants. The study started on 2004-08. Estimated completion is 2016-02.
What interventions are being tested in trial NCT00579683?
The interventions under investigation include: Tumor core biopsy for RNA isolation (OTHER).
Who is sponsoring clinical trial NCT00579683?
This trial is sponsored by Memorial Sloan Kettering Cancer Center, which has 1,884 total clinical trials registered on ClinicalTrials.gov.
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