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NCT00579371 · ClinicalTrials.gov registry record · Phase 1
Cadaveric Islet Transplantation in Patients With Insulin-Dependent Diabetes Mellitus
A Phase 1 study, sponsored by University of Nebraska.
- Terminated
- Registry status
- Phase 1
- Development phase
- 30
- Enrollment target
NCT00579371: Clinical Trial Phase 1 study, sponsored by University of Nebraska.
NCT00579371 is a Phase 1 study that was terminated before completion, run by University of Nebraska. The registered enrollment target is 30 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (50% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00579371, a Phase 1 study, was terminated before completion, sponsored by University of Nebraska.
- TERMINATED
- Registry status
- Phase 1
- Development phase
- 30 participants
- Enrollment target
Study Summary
We hypothesize that the following improvements to islet transplantation will increase the islet mass successfully isolated and allow for engraftment from a single pancreas. The improvements are: * Using Two-Layer method preservation to improve pancreas quality before islet isolation * Maintaining isolated islets in culture before transplantation * Using a steroid-free immunosuppression regimen * Transplanting the best combination of donor and recipient possible after human leukocyte antigens (HLA) screening and final crossmatching
Primary Outcome
Incidence of insulin independence with a single transplantation measured at one year post-transplantation.
Interventions
- DRUG Islets of Langerhans
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 30 participants |
| Start Date | 2004-03-17 |
| Est. Completion | 2011-03 |
| Phase | Phase 1 |
Why NCT00579371 stopped before completion
NCT00579371 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 30 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (50% lower).
The record links to 0 conditions, and to 1 intervention - of which Islets of Langerhans is the first listed.
NCT00579371 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00579371 about?
NCT00579371 is a clinical study titled "Cadaveric Islet Transplantation in Patients With Insulin-Dependent Diabetes Mellitus". We hypothesize that the following improvements to islet transplantation will increase the islet mass successfully isolated and allow for engraftment from a single pancreas. The improvements are: * Using Two-Layer method preservation to improve pancreas quality before islet isolation * Maintaining i...
What is the current status of trial NCT00579371?
This trial is currently terminated. It is a Phase 1 study. The enrollment target is 30 participants. The study started on 2004-03-17. Estimated completion is 2011-03.
What interventions are being tested in trial NCT00579371?
The interventions under investigation include: Islets of Langerhans (DRUG).
Who is sponsoring clinical trial NCT00579371?
This trial is sponsored by University of Nebraska, which has 407 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00579371's enrollment target sits among peer trials
30 1332nd of 2000 higher than 561 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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