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NCT00574834 · ClinicalTrials.gov registry record · Early Phase 1
Mechanisms of Ramipril Reduction in the Onset of Type 2 Diabetes
A Early Phase 1 study, sponsored by University of Maryland, Baltimore.
- Terminated
- Registry status
- Early Phase 1
- Development phase
- 17
- Enrollment target
NCT00574834: Clinical Trial Early Phase 1 study, sponsored by University of Maryland, Baltimore.
NCT00574834 is a Early Phase 1 study that was terminated before completion, run by University of Maryland, Baltimore. The registered enrollment target is 17 participants, below the 53-participant average among 2,764 other Early Phase 1 trials with a reported enrollment target (68% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00574834, a Early Phase 1 study, was terminated before completion, sponsored by University of Maryland, Baltimore.
- TERMINATED
- Registry status
- Early Phase 1
- Development phase
- 17 participants
- Enrollment target
Study Summary
The study will be focused on determining the integrated in-vivo mechanisms responsible for Ramipril's effects on delaying type 2 diabetes and restoring normal (blood sugar levels) glycemia in patients with impaired glucose tolerance. Hypothesis - Ramipril effects will delay the onset of type 2 diabetes and restore normal glycemia in patients with impaired glucose tolerance.
Primary Outcome
Measures of change in endogenous glucose production from baseline to final 30 minutes of clamp studies after 6 months of treatment.
Interventions
- DRUG Ramipril
- DRUG HCTZ-hydrochlorothiazide
- DRUG Ramipril+HCTZ
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 17 participants |
| Start Date | 2007-03 |
| Est. Completion | 2014-08 |
| Phase | Early Phase 1 |
Why NCT00574834 stopped before completion
NCT00574834 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 17 participants, a relatively small participant target, below the 53-participant average among 2,764 other Early Phase 1 trials with a reported enrollment target (68% lower).
The record links to 0 conditions, and to 3 interventions - of which Ramipril is the first listed.
NCT00574834 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00574834 about?
NCT00574834 is a clinical study titled "Mechanisms of Ramipril Reduction in the Onset of Type 2 Diabetes". The study will be focused on determining the integrated in-vivo mechanisms responsible for Ramipril's effects on delaying type 2 diabetes and restoring normal (blood sugar levels) glycemia in patients with impaired glucose tolerance. Hypothesis - Ramipril effects will delay the onset of type 2 diab...
What is the current status of trial NCT00574834?
This trial is currently terminated. It is a Early Phase 1 study. The enrollment target is 17 participants. The study started on 2007-03. Estimated completion is 2014-08.
What interventions are being tested in trial NCT00574834?
The interventions under investigation include: Ramipril (DRUG), HCTZ-hydrochlorothiazide (DRUG), Ramipril+HCTZ (DRUG).
Who is sponsoring clinical trial NCT00574834?
This trial is sponsored by University of Maryland, Baltimore, which has 560 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00574834's enrollment target sits among peer trials
17 1350th of 2000 higher than 632 of 2,000 other Early Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Early Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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