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NCT00553579 · ClinicalTrials.gov registry record
The Relationship of Residence Time and Visual Effect of Optive and Systane in Dry Eye Subjects
A clinical trial, sponsored by Southern California College of Optometry at Marshall B. Ketchum University.
- Completed
- Registry status
- 18
- Enrollment target
NCT00553579 is a clinical trial that has completed, run by Southern California College of Optometry at Marshall B. Ketchum University. The registered enrollment target is 18 participants.
The verdict
NCT00553579 has completed, sponsored by Southern California College of Optometry at Marshall B. Ketchum University.
- COMPLETED
- Registry status
- 18 participants
- Enrollment target
Study Summary
The benefits of artificial tears to relieve dry eye symptoms include, but are not limited to: stabilizing the tear film layer, fluid supplement action, improving visual acuity, and comfort. Studies have found a relationship between some of these benefits. For example, stabilization of the tear film is important not only to increase the tear break up time (TBUT), but is key in improving and maintaining visual acuity. These studies have alluded to the fact that there may or may not be a relationship between residence time and visual performance. Viscosity is one reason behind the uncertainty. Some solutions contain polymers which influence the ocular surface when contacted. This can impact residence time and ultimately visual performance. No prior research has explored the direct relationship between residence time and visual performance. Residence time refers to the duration at which the artificial tear resides on the eye. Methods have been developed to assess residence time by admixing fluorescent tracers to the solution and then measuring the amount of fluorescence over time. The caveat to methods using certain tracers has lead to uncertainty in elimination measurements due to corneal penetration or differing molecular weights (MW) from the active vehicle ingredient in the solution. For example, low-MW tracers can be eliminated at a different rate than higher-MW polymers. In addition, the low-MW tracers may be able to penetrate the corneal epithelium giving a false pre-corneal residence time. Meadows, Paugh, Joshi, and Mordaunt addressed this issue by developing a technique using a polymer which did not penetrate the cornea and had the same MW as the active ingredient in the solution FITC-dextran. Based on the assumption that similar weights are eliminated at the same rate, this technique has shown to be more economic, manageable, and amendable than previous procedures measuring residence time. Any ophthalmic drop has the potential to impact visual acuity upon in
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 18 participants |
| Start Date | 2007-06 |
| Est. Completion | 2008-05 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00553579
The ClinicalTrials.gov registry entry for NCT00553579 describes a study currently listed as completed, categorized as an unspecified phase. The registered enrollment target is 18 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Southern California College of Optometry at Marshall B. Ketchum University, which has 18 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 0 interventions.
NCT00553579 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT00553579 about?
NCT00553579 is a clinical study titled "The Relationship of Residence Time and Visual Effect of Optive and Systane in Dry Eye Subjects". The benefits of artificial tears to relieve dry eye symptoms include, but are not limited to: stabilizing the tear film layer, fluid supplement action, improving visual acuity, and comfort. Studies have found a relationship between some of these benefits. For example, stabilization of the tear film ...
What is the current status of trial NCT00553579?
This trial is currently completed. The enrollment target is 18 participants. The study started on 2007-06. Estimated completion is 2008-05.
Who is sponsoring clinical trial NCT00553579?
This trial is sponsored by Southern California College of Optometry at Marshall B. Ketchum University, which has 18 total clinical trials registered on ClinicalTrials.gov.
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