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NCT00549445 · ClinicalTrials.gov registry record
Effect of Macrolide Antibiotics on Airway Inflammation in People With Chronic Obstructive Pulmonary Disease (COPD)
A clinical trial, sponsored by University of Alabama at Birmingham.
- Completed
- Registry status
- 53
- Enrollment target
NCT00549445: Completed study, sponsored by University of Alabama at Birmingham.
NCT00549445 is a clinical trial that has completed, run by University of Alabama at Birmingham. The registered enrollment target is 53 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00549445 has completed, sponsored by University of Alabama at Birmingham.
- COMPLETED
- Registry status
- 53 participants
- Enrollment target
Study Summary
Chronic obstructive pulmonary disease (COPD) is a chronic lung disease. Azithromycin, an antibiotic, may be beneficial at reducing the symptoms and severity of the disease. This study will analyze previously collected study data to evaluate the anti-inflammatory properties of azithromycin and determine how azithromycin affects the frequency and severity of COPD exacerbations.
Primary Outcome
Nasopharyngeal swabs were obtained to determine if there is a reduction in PGP levels (including both PGP \& Neutrophil-PGP) after chronic treatment with azithromycin. Unblinding of the parent trial revealed that there were 18 sputum samples from 13 placebo-treated participants and 14 sputum samples from 8 azithromycin-treated participants collected at months 1 through 12 of treatment (with sputum samples not being available, this greatly reduced the sample size).
Interventions
- DRUG Placebo
- DRUG Azithromycin
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 53 participants |
| Start Date | 2007-08 |
| Est. Completion | 2012-07 |
What the finished NCT00549445 record still lists
NCT00549445 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 53 participants, a relatively small participant target.
The record links to 0 conditions, and to 2 interventions - of which Placebo is the first listed.
NCT00549445 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00549445 about?
NCT00549445 is a clinical study titled "Effect of Macrolide Antibiotics on Airway Inflammation in People With Chronic Obstructive Pulmonary Disease (COPD)". Chronic obstructive pulmonary disease (COPD) is a chronic lung disease. Azithromycin, an antibiotic, may be beneficial at reducing the symptoms and severity of the disease. This study will analyze previously collected study data to evaluate the anti-inflammatory properties of azithromycin and determ...
What is the current status of trial NCT00549445?
This trial is currently completed. The enrollment target is 53 participants. The study started on 2007-08. Estimated completion is 2012-07.
What interventions are being tested in trial NCT00549445?
The interventions under investigation include: Placebo (DRUG), Azithromycin (DRUG).
Who is sponsoring clinical trial NCT00549445?
This trial is sponsored by University of Alabama at Birmingham, which has 1,160 total clinical trials registered on ClinicalTrials.gov.
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