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NCT00528801 · ClinicalTrials.gov registry record
Examining Cognitive Function and Brain Abnormalities in Adults With Sickle Cell Disease
A clinical trial, sponsored by UCSF Benioff Children's Hospital Oakland.
- Completed
- Registry status
- 212
- Enrollment target
NCT00528801: Completed study, sponsored by UCSF Benioff Children's Hospital Oakland.
NCT00528801 is a clinical trial that has completed, run by UCSF Benioff Children's Hospital Oakland. The registered enrollment target is 212 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00528801 has completed, sponsored by UCSF Benioff Children's Hospital Oakland.
- COMPLETED
- Registry status
- 212 participants
- Enrollment target
Study Summary
Sickle cell disease (SCD), also known as sickle cell anemia, is an inherited blood disease that can cause intense pain episodes and may lead to organ failure. Preliminary studies have shown that adults with SCD may have brain abnormalities that contribute to problems with cognitive functioning, including attention and memory difficulties. This study will use brain magnetic resonance imaging (MRI) and neuropsychological testing to examine the differences in cognitive functioning in adults with SCD and adults without SCD. 212 subjects participated in this cross-sectional study consisting of screening questionnaires, a neuropsychological testing battery, and MRI testing. Enrollment into this study ended in May 2008.
Primary Outcome
Extent of neurocognitive dysfunction in neurologically asymptomatic adult patients with sickle cell disease as measured by WAIS-III performance IQ. This quotient is based on an average of 100, with a standard deviation of 15. The Wechsler intelligence scales are not considered adequate measures of extremely high and low intelligence (IQ scores above 160 and below 40, respectively). The performance IQ is derived from scores on seven subtests: picture completion, picture arrangement, block design,
Interventions
- PROCEDURE MRI
- BEHAVIORAL NP Battery
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 212 participants |
| Start Date | 2004-12 |
| Est. Completion | 2008-05 |
What the finished NCT00528801 record still lists
NCT00528801 is an observational study that tracks outcomes without assigning an intervention. The registered 212 participants enrollment target is mid-sized for trials with a published cap.
The record links to 0 conditions, and to 2 interventions - of which MRI is the first listed.
NCT00528801 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00528801 about?
NCT00528801 is a clinical study titled "Examining Cognitive Function and Brain Abnormalities in Adults With Sickle Cell Disease". Sickle cell disease (SCD), also known as sickle cell anemia, is an inherited blood disease that can cause intense pain episodes and may lead to organ failure. Preliminary studies have shown that adults with SCD may have brain abnormalities that contribute to problems with cognitive functioning, incl...
What is the current status of trial NCT00528801?
This trial is currently completed. The enrollment target is 212 participants. The study started on 2004-12. Estimated completion is 2008-05.
What interventions are being tested in trial NCT00528801?
The interventions under investigation include: MRI (PROCEDURE), NP Battery (BEHAVIORAL).
Who is sponsoring clinical trial NCT00528801?
This trial is sponsored by UCSF Benioff Children's Hospital Oakland, which has 52 total clinical trials registered on ClinicalTrials.gov.
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