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NCT00528788 · ClinicalTrials.gov registry record · Phase 4
How Vitamin D Analogues Affect Endothelial Cells in Patients on Dialysis
A Phase 4 study, sponsored by Duke University.
- Completed
- Registry status
- Phase 4
- Development phase
- 24
- Enrollment target
NCT00528788: Completed Phase 4 study, sponsored by Duke University.
NCT00528788 is a Phase 4 study that has completed, run by Duke University. The registered enrollment target is 24 participants, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (95% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00528788, a Phase 4 study, has completed, sponsored by Duke University.
- COMPLETED
- Registry status
- Phase 4
- Development phase
- 24 participants
- Enrollment target
Study Summary
Patients with chronic kidney disease and end stage renal disease have greater cardiovascular risk than the general population. Vitamin D analogues have been shown in observational studies to have mortality benefit for these patients. This study is designed to investigate doxercalciferol's effect on the vasculature (i.e. endothelial cell function) as a possible mechanism to explain the mortality benefit.
Primary Outcome
Endothelial cell function was assessed by performing flow mediated vasodilatation testing in a vascular laboratory prior to receiving doxercalciferol (either 2 mcg or 4 mcg 3 times per week at hemodialysis) and then after receiving the drug for 30 days.
Interventions
- DRUG doxercalciferol
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 24 participants |
| Start Date | 2007-09 |
| Est. Completion | 2012-08 |
| Phase | Phase 4 |
What the finished NCT00528788 record still lists
NCT00528788 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 24 participants, a relatively small participant target, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (95% lower).
The record links to 0 conditions, and to 1 intervention - of which doxercalciferol is the first listed.
NCT00528788 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00528788 about?
NCT00528788 is a clinical study titled "How Vitamin D Analogues Affect Endothelial Cells in Patients on Dialysis". Patients with chronic kidney disease and end stage renal disease have greater cardiovascular risk than the general population. Vitamin D analogues have been shown in observational studies to have mortality benefit for these patients. This study is designed to investigate doxercalciferol's effect on ...
What is the current status of trial NCT00528788?
This trial is currently completed. It is a Phase 4 study. The enrollment target is 24 participants. The study started on 2007-09. Estimated completion is 2012-08.
What interventions are being tested in trial NCT00528788?
The interventions under investigation include: doxercalciferol (DRUG).
Who is sponsoring clinical trial NCT00528788?
This trial is sponsored by Duke University, which has 1,725 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00528788's enrollment target sits among peer trials
24 1699th of 2000 higher than 276 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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