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Bortezomib, Melphalan, and Dexamethasone in Treating Patients With Primary Amyloidosis or Light Chain Deposition Disease
NCT00520767 · View on ClinicalTrials.gov ↗
Study Summary
RATIONALE: Giving bortezomib together with melphalan and dexamethasone may be an effective treatment for primary amyloidosis and light chain deposition disease. PURPOSE: This phase II trial is studying how well giving bortezomib together with melphalan and dexamethasone works in treating patients with primary amyloidosis or light chain deposition disease.
Conditions Studied
Interventions
- GENETIC microarray analysis
- DRUG dexamethasone
- DRUG melphalan
- OTHER flow cytometry
- DRUG bortezomib
Study Locations (7)
Michigan
- Barbara Ann Karmanos Cancer Institute — Detroit
- Josephine Ford Cancer Center at Henry Ford Hospital — Detroit
- Providence Cancer Institute at Providence Hospital - Southfield Campus — Southfield
Colorado
- Rocky Mountain Cancer Centers/Rocky Mountain Blood & Marrow Transplant Program — Denver
Massachusetts
- Boston University Cancer Research Center — Boston
North Carolina
- Duke Comprehensive Cancer Center — Durham
Pennsylvania
- UPMC Cancer Centers — Pittsburgh
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 35 participants |
| Start Date | 2007-09 |
| Est. Completion | 2019-06-06 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00520767
The ClinicalTrials.gov registry entry for NCT00520767 describes a study currently listed as completed. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 35 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Barbara Ann Karmanos Cancer Institute, which has 97 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 2 conditions, with Light Chain Deposition Disease appearing as the primary indexed condition, and to 5 interventions — of which microarray analysis is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT00520767 reports 7 study locations spanning 5 distinct geographic areas — top geographies include Michigan, Colorado, Massachusetts. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT00520767 about?
NCT00520767 is a clinical study titled "Bortezomib, Melphalan, and Dexamethasone in Treating Patients With Primary Amyloidosis or Light Chain Deposition Disease". RATIONALE: Giving bortezomib together with melphalan and dexamethasone may be an effective treatment for primary amyloidosis and light chain deposition disease. PURPOSE: This phase II trial is studying how well giving bortezomib together with melphalan and dexamethasone works in treating patients w...
What is the current status of trial NCT00520767?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 35 participants. The study started on 2007-09. Estimated completion is 2019-06-06.
What conditions does trial NCT00520767 study?
This clinical trial studies the following conditions: Light Chain Deposition Disease, Primary Systemic Amyloidosis. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT00520767?
The interventions under investigation include: microarray analysis (GENETIC), dexamethasone (DRUG), melphalan (DRUG), flow cytometry (OTHER), bortezomib (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT00520767?
This trial is sponsored by Barbara Ann Karmanos Cancer Institute, which has 97 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT00520767 being conducted?
This trial has 7 study locations across Colorado, Massachusetts, Michigan, North Carolina, Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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