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NCT00508118 · ClinicalTrials.gov registry record · Phase 2
NICardipine Neuroprotection in AortiC Surgery (NICNACS)
A Phase 2 study, sponsored by Duke University.
- Terminated
- Registry status
- Phase 2
- Development phase
- 7
- Enrollment target
NCT00508118: Clinical Trial Phase 2 study, sponsored by Duke University.
NCT00508118 is a Phase 2 study that was terminated before completion, run by Duke University. The registered enrollment target is 7 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (95% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00508118, a Phase 2 study, was terminated before completion, sponsored by Duke University.
- TERMINATED
- Registry status
- Phase 2
- Development phase
- 7 participants
- Enrollment target
Study Summary
Objective The objective of this study is to discover whether an infusion of nicardipine is able to reduce the time taken to achieve electrocerebral silence (ECS) during cardiopulmonary bypass (CPB) for aortic surgery. Hypothesis By inhibiting cold-induced cerebral vasoconstriction, nicardipine will maintain cerebral blood flow and allow more rapid cooling of the brain during CPB. This will manifest as a reduction in the time taken to achieve ECS and also as a reduction in overall CPB time.
Interventions
- DRUG Nicardipine
- DRUG 0.9% saline
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 7 participants |
| Start Date | 2008-01 |
| Est. Completion | 2008-04 |
| Phase | Phase 2 |
Why NCT00508118 stopped before completion
NCT00508118 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 7 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (95% lower).
The record links to 0 conditions, and to 2 interventions - of which Nicardipine is the first listed.
NCT00508118 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00508118 about?
NCT00508118 is a clinical study titled "NICardipine Neuroprotection in AortiC Surgery (NICNACS)". Objective The objective of this study is to discover whether an infusion of nicardipine is able to reduce the time taken to achieve electrocerebral silence (ECS) during cardiopulmonary bypass (CPB) for aortic surgery. Hypothesis By inhibiting cold-induced cerebral vasoconstriction, nicardipine wi...
What is the current status of trial NCT00508118?
This trial is currently terminated. It is a Phase 2 study. The enrollment target is 7 participants. The study started on 2008-01. Estimated completion is 2008-04.
What interventions are being tested in trial NCT00508118?
The interventions under investigation include: Nicardipine (DRUG), 0.9% saline (DRUG).
Who is sponsoring clinical trial NCT00508118?
This trial is sponsored by Duke University, which has 1,725 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00508118's enrollment target sits among peer trials
7 1996th of 2000 higher than 5 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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