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NCT00499460 · ClinicalTrials.gov registry record · Phase 4
Effects of Garlic Supplements on Opioids in Healthy Volunteers
A Phase 4 study of Healthy, no Evidence of Disease, sponsored by Fred Hutchinson Cancer Center.
- Completed
- Registry status
- Phase 4
- Development phase
- 15
- Enrollment target
- 1
- Study location
NCT00499460: Completed Phase 4 study of Healthy, no Evidence of Disease, sponsored by Fred Hutchinson Cancer Center.
NCT00499460 is a Phase 4 study of Healthy, no Evidence of Disease that has completed, run by Fred Hutchinson Cancer Center. The registered enrollment target is 15 participants, below the 176-participant average among 11 other Healthy, no Evidence of Disease trials with a reported enrollment target (91% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00499460, a Phase 4 study of Healthy, no Evidence of Disease, has completed, sponsored by Fred Hutchinson Cancer Center.
- COMPLETED
- Registry status
- Phase 4
- Development phase
- 15 participants
- Enrollment target
- 1
- Study location
Study Summary
RATIONALE: Garlic supplements may alter the pharmacokinetics of oxycodone, thereby affecting its effectiveness as an opioid analgesic for the relief of moderate or severe pain. PURPOSE: This randomized phase 4 trial is studying how garlic supplements may change the pharmacokinetics of oxycodone and its analgesic and side effects in healthy volunteers.
Primary Outcome
Oxycodone oral clearance is computed by Dose/AUC, where AUC is the area under the plasma oxycodone concentration-time curve from time zero to infinity. Oral clearance is a measure of the rate at which oxycodone is cleared from the body via metabolism.
Conditions Studied
Interventions
- DIETARY_SUPPLEMENT garlic powder tablets
- DRUG oxycodone
Study Locations (1)
Washington
- Fred Hutchinson Cancer Research Center - Seattle
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 15 participants |
| Start Date | 2006-11 |
| Est. Completion | 2008-08 |
| Phase | Phase 4 |
What the finished NCT00499460 record still lists
NCT00499460 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 15 participants, a relatively small participant target, below the 176-participant average among 11 other Healthy, no Evidence of Disease trials with a reported enrollment target (91% lower).
The record links to 1 condition, with Healthy, no Evidence of Disease appearing as the primary indexed condition, and to 2 interventions - of which garlic powder tablets is the first listed.
NCT00499460 reports a single indexed study location in Washington.
Frequently Asked Questions
What is clinical trial NCT00499460 about?
NCT00499460 is a clinical study titled "Effects of Garlic Supplements on Opioids in Healthy Volunteers". RATIONALE: Garlic supplements may alter the pharmacokinetics of oxycodone, thereby affecting its effectiveness as an opioid analgesic for the relief of moderate or severe pain. PURPOSE: This randomized phase 4 trial is studying how garlic supplements may change the pharmacokinetics of oxycodone and...
What is the current status of trial NCT00499460?
This trial is currently completed. It is a Phase 4 study. The enrollment target is 15 participants. The study started on 2006-11. Estimated completion is 2008-08.
What conditions does trial NCT00499460 study?
This clinical trial studies the following conditions: Healthy, no Evidence of Disease.
What interventions are being tested in trial NCT00499460?
The interventions under investigation include: garlic powder tablets (DIETARY_SUPPLEMENT), oxycodone (DRUG).
Who is sponsoring clinical trial NCT00499460?
This trial is sponsored by Fred Hutchinson Cancer Center, which has 483 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00499460 being conducted?
This trial has 1 study location across Washington. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Healthy, no Evidence of Disease
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT00499460's enrollment target sits among peer trials
15 10th of 11 higher than 2 of 11 other Healthy, no Evidence of Disease trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Healthy, no Evidence of Disease trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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