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NCT00487084 · ClinicalTrials.gov registry record · NA
Effect of Timing on Efficacy of Morphine Analgesia After 2-chloroprocaine Anesthesia
A NA study, sponsored by Northwestern University.
- Completed
- Registry status
- NA
- Development phase
- 136
- Enrollment target
NCT00487084 is a NA study that has completed, run by Northwestern University. The registered enrollment target is 136 participants.
The verdict
NCT00487084, a NA study, has completed, sponsored by Northwestern University.
- COMPLETED
- Registry status
- NA
- Development phase
- 136 participants
- Enrollment target
Study Summary
Epidural chloroprocaine is often used in obstetrical anesthesia because of its fast onset and short duration. These properties make it an ideal drug to use for epidural anesthesia in patients undergoing postpartum tubal ligation. When epidural morphine is given after chloroprocaine, there is a decreased efficacy of analgesia as compared to lidocaine (1). Several studies have hypothesized a specific opioid receptor mediated antagonism of chloroprocaine (2,3). Karambelkar raised the question whether this decreased efficacy is due to a disparity between the time the chloroprocaine anesthesia resolves and the onset of epidural morphine analgesia, resulting in a time window of pain (2). The duration of action of epidural 2-CP anesthesia is 30-45 minutes and the onset of epidural morphine analgesia is 60-70 minutes, therefore the regression of sensory blockade before the onset of the morphine analgesia could result in a window of pain (2). Hess and colleagues studied epidural morphine analgesia and women who had a Cesarean delivery under spinal bupivacaine anesthesia (3). Subjects were randomized to receive epidural 2-CP and morphine or epidural saline and morphine. There was no difference in postoperative analgesia between the two groups (3 and personal communication, Dr. Philip Hess). A literature search cross referencing epidural chloroprocaine, using Pub Med, did not produce any articles comparing epidural morphine given before the procedure (in an attempt to time the onset of analgesia with the resolution of chloroprocaine anesthesia) to the standard administration time after the procedure.
Interventions
- DRUG Morphine-CP-saline (MCS)
- DRUG saline-2CP-morphine (SCM)
- DRUG saline-lidocaine-morphine (SLM)
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 136 participants |
| Start Date | 2004-08 |
| Est. Completion | 2008-09 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00487084
The ClinicalTrials.gov registry entry for NCT00487084 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 136 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Northwestern University, which has 1,209 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 3 interventions - of which Morphine-CP-saline (MCS) is the first listed.
NCT00487084 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT00487084 about?
NCT00487084 is a clinical study titled "Effect of Timing on Efficacy of Morphine Analgesia After 2-chloroprocaine Anesthesia". Epidural chloroprocaine is often used in obstetrical anesthesia because of its fast onset and short duration. These properties make it an ideal drug to use for epidural anesthesia in patients undergoing postpartum tubal ligation. When epidural morphine is given after chloroprocaine, there is a decre...
What is the current status of trial NCT00487084?
This trial is currently completed. It is a NA study. The enrollment target is 136 participants. The study started on 2004-08. Estimated completion is 2008-09.
What interventions are being tested in trial NCT00487084?
The interventions under investigation include: Morphine-CP-saline (MCS) (DRUG), saline-2CP-morphine (SCM) (DRUG), saline-lidocaine-morphine (SLM) (DRUG).
Who is sponsoring clinical trial NCT00487084?
This trial is sponsored by Northwestern University, which has 1,209 total clinical trials registered on ClinicalTrials.gov.
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