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NCT00460603 · ClinicalTrials.gov registry record · Phase 1
Study With AG-013736 Combined With Chemotherapy And Bevacizumab In Patients With Metastatic Colorectal Cancer
A Phase 1 study, sponsored by Pfizer.
- Completed
- Registry status
- Phase 1
- Development phase
- 187
- Enrollment target
NCT00460603: Completed Phase 1 study, sponsored by Pfizer.
NCT00460603 is a Phase 1 study that has completed, run by Pfizer. The registered enrollment target is 187 participants, above the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (212% higher). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00460603, a Phase 1 study, has completed, sponsored by Pfizer.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 187 participants
- Enrollment target
Study Summary
To determine the safety and efficacy of AG-013736 in combination with other standard of care medication in patients with first line metastatic colorectal cancer.
Primary Outcome
Percentage of participants with objective response (OR) based assessment of confirmed complete response(CR) or confirmed partial response (PR) according to Response Evaluation Criteria in Solid Tumors (RECIST). Confirmed CR defined as disappearance of all lesions and no appearance of new lesions. Confirmed PR defined as \>=30 percent (%) decrease in sum of the longest dimensions (LD) of the target lesions taking as reference the baseline sum LD , without progression of nontarget lesions and no a
Interventions
- DRUG bevacizumab
- DRUG AG-013736 (axitinib)
- DRUG AG-013726
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 187 participants |
| Start Date | 2006-01 |
| Est. Completion | 2012-11 |
| Phase | Phase 1 |
What the finished NCT00460603 record still lists
NCT00460603 is an interventional study that assigns participants to a tested intervention. The registered 187 participants enrollment target is mid-sized for trials with a published cap, above the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (212% higher).
The record links to 0 conditions, and to 3 interventions - of which bevacizumab is the first listed.
NCT00460603 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00460603 about?
NCT00460603 is a clinical study titled "Study With AG-013736 Combined With Chemotherapy And Bevacizumab In Patients With Metastatic Colorectal Cancer". To determine the safety and efficacy of AG-013736 in combination with other standard of care medication in patients with first line metastatic colorectal cancer.
What is the current status of trial NCT00460603?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 187 participants. The study started on 2006-01. Estimated completion is 2012-11.
What interventions are being tested in trial NCT00460603?
The interventions under investigation include: bevacizumab (DRUG), AG-013736 (axitinib) (DRUG), AG-013726 (DRUG).
Who is sponsoring clinical trial NCT00460603?
This trial is sponsored by Pfizer, which has 1,845 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00460603's enrollment target sits among peer trials
187 290th of 2000 higher than 1,710 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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