Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT00458419 · ClinicalTrials.gov registry record · NA
Role of Endorphins in the Perception of Dyspnea in Patients With Chronic Obstructive Pulmonary Disease
A NA study, sponsored by Dartmouth-Hitchcock Medical Center.
- Completed
- Registry status
- NA
- Development phase
- 17
- Enrollment target
NCT00458419 is a NA study that has completed, run by Dartmouth-Hitchcock Medical Center. The registered enrollment target is 17 participants.
The verdict
NCT00458419, a NA study, has completed, sponsored by Dartmouth-Hitchcock Medical Center.
- COMPLETED
- Registry status
- NA
- Development phase
- 17 participants
- Enrollment target
Study Summary
Endorphins are naturally occurring narcotic substances that are released when individuals perform exercise. The hypothesis of the study is that endorphins reduce the severity of breathlessness during exercise in patients with chronic obstructive pulmonary disease (COPD). The initial five visits include familiarization and validation of a computerized system for patients to report dyspnea and leg discomfort continuously during exercise testing. At Visits 6 and 7 blood is drawn to measure serum endorphin levels pre-exercise, end exercise, and 30 minutes after exercise. Normal saline or naloxone is given intravenously 5 minutes prior to exercise in a double-blinded design. The primary outcome is the slope of oxygen consumption - dyspnea.
Interventions
- DRUG naloxone versus placebo
- DRUG intravenous injection of normal saline or naloxone
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 17 participants |
| Start Date | 2005-09 |
| Est. Completion | 2007-05 |
| Phase | NA |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00458419
The ClinicalTrials.gov registry entry for NCT00458419 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 17 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Dartmouth-Hitchcock Medical Center, which has 427 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 2 interventions - of which naloxone versus placebo is the first listed.
NCT00458419 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT00458419 about?
NCT00458419 is a clinical study titled "Role of Endorphins in the Perception of Dyspnea in Patients With Chronic Obstructive Pulmonary Disease". Endorphins are naturally occurring narcotic substances that are released when individuals perform exercise. The hypothesis of the study is that endorphins reduce the severity of breathlessness during exercise in patients with chronic obstructive pulmonary disease (COPD). The initial five visits incl...
What is the current status of trial NCT00458419?
This trial is currently completed. It is a NA study. The enrollment target is 17 participants. The study started on 2005-09. Estimated completion is 2007-05.
What interventions are being tested in trial NCT00458419?
The interventions under investigation include: naloxone versus placebo (DRUG), intravenous injection of normal saline or naloxone (DRUG).
Who is sponsoring clinical trial NCT00458419?
This trial is sponsored by Dartmouth-Hitchcock Medical Center, which has 427 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
Explore more on PlainTrial
Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.