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NCT00458419 · ClinicalTrials.gov registry record · NA
Role of Endorphins in the Perception of Dyspnea in Patients With Chronic Obstructive Pulmonary Disease
A NA study, sponsored by Dartmouth-Hitchcock Medical Center.
- Completed
- Registry status
- NA
- Development phase
- 17
- Enrollment target
NCT00458419: Completed NA study, sponsored by Dartmouth-Hitchcock Medical Center.
NCT00458419 is a NA study that has completed, run by Dartmouth-Hitchcock Medical Center. The registered enrollment target is 17 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00458419, a NA study, has completed, sponsored by Dartmouth-Hitchcock Medical Center.
- COMPLETED
- Registry status
- NA
- Development phase
- 17 participants
- Enrollment target
Study Summary
Endorphins are naturally occurring narcotic substances that are released when individuals perform exercise. The hypothesis of the study is that endorphins reduce the severity of breathlessness during exercise in patients with chronic obstructive pulmonary disease (COPD). The initial five visits include familiarization and validation of a computerized system for patients to report dyspnea and leg discomfort continuously during exercise testing. At Visits 6 and 7 blood is drawn to measure serum endorphin levels pre-exercise, end exercise, and 30 minutes after exercise. Normal saline or naloxone is given intravenously 5 minutes prior to exercise in a double-blinded design. The primary outcome is the slope of oxygen consumption - dyspnea.
Interventions
- DRUG naloxone versus placebo
- DRUG intravenous injection of normal saline or naloxone
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 17 participants |
| Start Date | 2005-09 |
| Est. Completion | 2007-05 |
| Phase | NA |
What the finished NCT00458419 record still lists
NCT00458419 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 17 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower).
The record links to 0 conditions, and to 2 interventions - of which naloxone versus placebo is the first listed.
NCT00458419 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00458419 about?
NCT00458419 is a clinical study titled "Role of Endorphins in the Perception of Dyspnea in Patients With Chronic Obstructive Pulmonary Disease". Endorphins are naturally occurring narcotic substances that are released when individuals perform exercise. The hypothesis of the study is that endorphins reduce the severity of breathlessness during exercise in patients with chronic obstructive pulmonary disease (COPD). The initial five visits incl...
What is the current status of trial NCT00458419?
This trial is currently completed. It is a NA study. The enrollment target is 17 participants. The study started on 2005-09. Estimated completion is 2007-05.
What interventions are being tested in trial NCT00458419?
The interventions under investigation include: naloxone versus placebo (DRUG), intravenous injection of normal saline or naloxone (DRUG).
Who is sponsoring clinical trial NCT00458419?
This trial is sponsored by Dartmouth-Hitchcock Medical Center, which has 427 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00458419's enrollment target sits among peer trials
17 1871st of 2000 higher than 130 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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