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NCT00455793 · ClinicalTrials.gov registry record
Subclinical Atherosclerosis in HIV-infected Patients
A clinical trial of HIV Infections and Coronary Atherosclerosis, sponsored by Massachusetts General Hospital.
- Completed
- Registry status
- 263
- Enrollment target
- 1
- Study location
NCT00455793: Completed study of HIV Infections and Coronary Atherosclerosis, sponsored by Massachusetts General Hospital.
NCT00455793 is a study of HIV Infections and Coronary Atherosclerosis that has completed, run by Massachusetts General Hospital. The registered enrollment target is 263 participants, below the 445-participant average among 542 other HIV Infections trials with a reported enrollment target (41% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00455793, a study of HIV Infections and Coronary Atherosclerosis, has completed, sponsored by Massachusetts General Hospital.
- COMPLETED
- Registry status
- 263 participants
- Enrollment target
- 1
- Study location
Study Summary
We will obtain data using multi-slice CT technology to detect subclinical coronary disease in the HIV population. Determination of subclinical cardiovascular disease using noninvasive technology and elucidation of the associated risk factors will help to guide targeted therapy to prevent cardiovascular events in this patient population. We will investigate the prevalence of coronary plaque lesions and coronary artery calcifications in men and women with HIV disease as determined by 64-row multidetector computed tomography (MDCT) and MDCT coronary angiography in comparison to age-matched control subjects without HIV infection. We hypothesize that evidence of coronary artery calcification and coronary plaque lesions as seen by MDCT will be present in individuals with HIV more than non-HIV control subjects of the same age. We also hypothesize the degree of atherosclerosis will be increased in HIV patients compared to control subjects. We will evaluate the metabolic and inflammatory factors associated with coronary artery disease in HIV-infected individuals. We hypothesize that traditional cardiac risk factors as well as metabolic and inflammatory changes associated with HIV and its treatment such as dyslipidemia, increased secretion of inflammatory markers, decreased adiponectin, increased insulin resistance and increased visceral fat may be associated with coronary artery disease in HIV-infected individuals.
Conditions Studied
Study Locations (1)
Massachusetts
- Massachusetts General Hospital - Boston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 263 participants |
| Start Date | 2006-06 |
| Est. Completion | 2013-02 |
What the finished NCT00455793 record still lists
NCT00455793 is an observational study that tracks outcomes without assigning an intervention. The registered 263 participants enrollment target is mid-sized for trials with a published cap, below the 445-participant average among 542 other HIV Infections trials with a reported enrollment target (41% lower).
The record links to 2 conditions, with HIV Infections appearing as the primary indexed condition, and to 0 interventions.
NCT00455793 reports a single indexed study location in Massachusetts.
Frequently Asked Questions
What is clinical trial NCT00455793 about?
NCT00455793 is a clinical study titled "Subclinical Atherosclerosis in HIV-infected Patients". We will obtain data using multi-slice CT technology to detect subclinical coronary disease in the HIV population. Determination of subclinical cardiovascular disease using noninvasive technology and elucidation of the associated risk factors will help to guide targeted therapy to prevent cardiovascu...
What is the current status of trial NCT00455793?
This trial is currently completed. The enrollment target is 263 participants. The study started on 2006-06. Estimated completion is 2013-02.
What conditions does trial NCT00455793 study?
This clinical trial studies the following conditions: HIV Infections, Coronary Atherosclerosis.
Who is sponsoring clinical trial NCT00455793?
This trial is sponsored by Massachusetts General Hospital, which has 2,032 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00455793 being conducted?
This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT00455793's enrollment target sits among peer trials
263 136th of 542 higher than 407 of 542 other HIV Infections trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other HIV Infections trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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