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NCT00423878 · ClinicalTrials.gov registry record · Phase 4
Comparison of Antipsychotics for Metabolic Problems in Schizophrenia or Schizoaffective Disorder
A Phase 4 study, sponsored by National Institute of Mental Health (NIMH).
- Completed
- Registry status
- Phase 4
- Development phase
- 215
- Enrollment target
NCT00423878: Completed Phase 4 study, sponsored by National Institute of Mental Health (NIMH).
NCT00423878 is a Phase 4 study that has completed, run by National Institute of Mental Health (NIMH). The registered enrollment target is 215 participants, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (58% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00423878, a Phase 4 study, has completed, sponsored by National Institute of Mental Health (NIMH).
- COMPLETED
- Registry status
- Phase 4
- Development phase
- 215 participants
- Enrollment target
Study Summary
The study will compare the effectiveness of antipsychotic medications for patients with schizophrenia or schizoaffective disorder for whom a medication change may be indicated because of an increased risk of cardiovascular disease.
Primary Outcome
Change in non-HDL cholesterol measured at baseline and every 4 weeks for 24 weeks. The efficacy analysis corresponded to a comparison of change in non-HDL cholesterol from baseline to 24 weeks between treatment groups (stay versus switch). Repeated measurements mixed effects linear models were fit for the primary analysis.
Interventions
- DRUG Risperidone
- DRUG Olanzapine
- DRUG Quetiapine
- DRUG Aripiprazole
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 215 participants |
| Start Date | 2007-01 |
| Est. Completion | 2010-03 |
| Phase | Phase 4 |
What the finished NCT00423878 record still lists
NCT00423878 is an interventional study that assigns participants to a tested intervention. The registered 215 participants enrollment target is mid-sized for trials with a published cap, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (58% lower).
The record links to 0 conditions, and to 4 interventions - of which Risperidone is the first listed.
NCT00423878 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00423878 about?
NCT00423878 is a clinical study titled "Comparison of Antipsychotics for Metabolic Problems in Schizophrenia or Schizoaffective Disorder". The study will compare the effectiveness of antipsychotic medications for patients with schizophrenia or schizoaffective disorder for whom a medication change may be indicated because of an increased risk of cardiovascular disease.
What is the current status of trial NCT00423878?
This trial is currently completed. It is a Phase 4 study. The enrollment target is 215 participants. The study started on 2007-01. Estimated completion is 2010-03.
What interventions are being tested in trial NCT00423878?
The interventions under investigation include: Risperidone (DRUG), Olanzapine (DRUG), Quetiapine (DRUG), Aripiprazole (DRUG).
Who is sponsoring clinical trial NCT00423878?
This trial is sponsored by National Institute of Mental Health (NIMH), which has 343 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00423878's enrollment target sits among peer trials
215 394th of 2000 higher than 1,607 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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