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NCT00411827 · ClinicalTrials.gov registry record · NA
Goblet Cell Response and Dry Eye Symptoms After PRK and LASIK
A NA study, sponsored by Walter Reed National Military Medical Center.
- Completed
- Registry status
- NA
- Development phase
- 146
- Enrollment target
NCT00411827: Completed NA study, sponsored by Walter Reed National Military Medical Center.
NCT00411827 is a NA study that has completed, run by Walter Reed National Military Medical Center. The registered enrollment target is 146 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (90% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00411827, a NA study, has completed, sponsored by Walter Reed National Military Medical Center.
- COMPLETED
- Registry status
- NA
- Development phase
- 146 participants
- Enrollment target
Study Summary
Purpose: To develop a screening metric by examining both the characteristics of the preoperative tear film and the intracellular signaling pathways of conjunctival goblet cells in order to determine if there are certain characteristics which might predict those patients who will experience serious dry eye symptoms and complications after refractive surgery. Research Design: This study is a twelve-month prospective non-randomized investigation. Methodology: In conjunction with psychometric questionnaires and various measures of tear film quality (e.g. Schirmer's test, tear break up time, etc), impression cytology will be used to assess the intracellular signaling pathways of conjunctival goblet cells and to determine if alterations in this pathway exist. Alterations in this pathway would result in a reduced response by the mucin secreting conjunctival goblet cells thereby promoting the development of dry eye after refractive surgery.
Interventions
- PROCEDURE PRK with conjunctival impression cytology before and after surgery
- PROCEDURE LASIK with conjunctival impression cytology before and after surgery
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 146 participants |
| Start Date | 2008-01 |
| Est. Completion | 2016-05 |
| Phase | NA |
What the finished NCT00411827 record still lists
NCT00411827 is an interventional study that assigns participants to a tested intervention. The registered 146 participants enrollment target is mid-sized for trials with a published cap, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (90% lower).
The record links to 0 conditions, and to 2 interventions - of which PRK with conjunctival impression cytology before and after surgery is the first listed.
NCT00411827 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00411827 about?
NCT00411827 is a clinical study titled "Goblet Cell Response and Dry Eye Symptoms After PRK and LASIK". Purpose: To develop a screening metric by examining both the characteristics of the preoperative tear film and the intracellular signaling pathways of conjunctival goblet cells in order to determine if there are certain characteristics which might predict those patients who will experience serious d...
What is the current status of trial NCT00411827?
This trial is currently completed. It is a NA study. The enrollment target is 146 participants. The study started on 2008-01. Estimated completion is 2016-05.
What interventions are being tested in trial NCT00411827?
The interventions under investigation include: PRK with conjunctival impression cytology before and after surgery (PROCEDURE), LASIK with conjunctival impression cytology before and after surgery (PROCEDURE).
Who is sponsoring clinical trial NCT00411827?
This trial is sponsored by Walter Reed National Military Medical Center, which has 48 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00411827's enrollment target sits among peer trials
146 704th of 2000 higher than 1,296 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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