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NCT00408499 · ClinicalTrials.gov registry record · Phase 1
Erlotinib and Cetuximab in Treating Patients With Advanced Solid Tumors With Emphasis on Non-Small Cell Lung Cancer
A Phase 1 study of Lung Cancer and Unspecified Adult Solid Tumor, Protocol Specific, sponsored by University of California, Davis.
- Completed
- Registry status
- Phase 1
- Development phase
- 64
- Enrollment target
- 1
- Study location
NCT00408499: Completed Phase 1 study of Lung Cancer and Unspecified Adult Solid Tumor, Protocol Specific, sponsored by University of California, Davis.
NCT00408499 is a Phase 1 study of Lung Cancer and Unspecified Adult Solid Tumor, Protocol Specific that has completed, run by University of California, Davis. The registered enrollment target is 64 participants, below the 936-participant average among 409 other Lung Cancer trials with a reported enrollment target (93% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00408499, a Phase 1 study of Lung Cancer and Unspecified Adult Solid Tumor, Protocol Specific, has completed, sponsored by University of California, Davis.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 64 participants
- Enrollment target
- 1
- Study location
Study Summary
RATIONALE: Erlotinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Monoclonal antibodies, such as cetuximab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Giving erlotinib together with cetuximab may kill more tumor cells. PURPOSE: This phase I/II trial is studying the side effects and best dose of erlotinib and cetuximab and to see how well they work in treating patients with advanced solid tumors or progressive or recurrent stage III or stage IV non-small cell lung cancer.
Primary Outcome
Patients will be followed during cycle 1 for the occurrence of a protocol defined dose limiting toxicity
Conditions Studied
Interventions
- DRUG cetuximab
- DRUG erlotinib
Study Locations (1)
California
- University of California Davis Cancer Center - Sacramento
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 64 participants |
| Start Date | 2006-08 |
| Est. Completion | 2013-01 |
| Phase | Phase 1 |
What the finished NCT00408499 record still lists
NCT00408499 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 64 participants, a relatively small participant target, below the 936-participant average among 409 other Lung Cancer trials with a reported enrollment target (93% lower).
The record links to 2 conditions, with Lung Cancer appearing as the primary indexed condition, and to 2 interventions - of which cetuximab is the first listed.
NCT00408499 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT00408499 about?
NCT00408499 is a clinical study titled "Erlotinib and Cetuximab in Treating Patients With Advanced Solid Tumors With Emphasis on Non-Small Cell Lung Cancer". RATIONALE: Erlotinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Monoclonal antibodies, such as cetuximab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or ...
What is the current status of trial NCT00408499?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 64 participants. The study started on 2006-08. Estimated completion is 2013-01.
What conditions does trial NCT00408499 study?
This clinical trial studies the following conditions: Lung Cancer, Unspecified Adult Solid Tumor, Protocol Specific.
What interventions are being tested in trial NCT00408499?
The interventions under investigation include: cetuximab (DRUG), erlotinib (DRUG).
Who is sponsoring clinical trial NCT00408499?
This trial is sponsored by University of California, Davis, which has 657 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00408499 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Lung Cancer
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT00408499's enrollment target sits among peer trials
64 236th of 409 higher than 173 of 409 other Lung Cancer trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Lung Cancer trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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