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Sunitinib Malate in Treating Patients With Thyroid Cancer That Did Not Respond to Iodine I 131 and Cannot Be Removed by Surgery
NCT00381641 · View on ClinicalTrials.gov ↗
Study Summary
This phase II trial studies how well sunitinib malate works in treating patients with thyroid cancer that did not respond to iodine I 131 (radioactive iodine) and cannot be removed by surgery. Sunitinib malate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor.
Conditions Studied
Interventions
- OTHER Laboratory Biomarker Analysis
- DRUG Sunitinib
- OTHER Pharmacogenomic Study
- DRUG Sunitinib Malate
Study Locations (17)
Illinois
- University of Chicago Comprehensive Cancer Center — Chicago
- Decatur Memorial Hospital — Decatur
- NorthShore University HealthSystem-Evanston Hospital — Evanston
- Ingalls Memorial Hospital — Harvey
- Duly Health and Care Joliet — Joliet
- Loyola University Medical Center — Maywood
- Illinois CancerCare-Peoria — Peoria
- Central Illinois Hematology Oncology Center — Springfield
- Southern Illinois University School of Medicine — Springfield
Indiana
- Fort Wayne Medical Oncology and Hematology Inc-Parkview — Fort Wayne
- Northern Indiana Cancer Research Consortium — South Bend
Michigan
- University of Michigan Comprehensive Cancer Center — Ann Arbor
- Oncology Care Associates PLLC — Saint Joseph
Maryland
- University of Maryland/Greenebaum Cancer Center — Baltimore
Missouri
- Mercy Hospital Saint Louis — St Louis
Texas
- M D Anderson Cancer Center — Houston
Wisconsin
- Medical College of Wisconsin — Milwaukee
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 63 participants |
| Start Date | 2006-08-29 |
| Est. Completion | 2024-12-10 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00381641
The ClinicalTrials.gov registry entry for NCT00381641 describes a study currently listed as completed. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 63 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is National Cancer Institute (NCI), which has 2,390 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 10 conditions, with Recurrent Thyroid Gland Carcinoma appearing as the primary indexed condition, and to 4 interventions — of which Laboratory Biomarker Analysis is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT00381641 reports 17 study locations spanning 7 distinct geographic areas — top geographies include Illinois, Indiana, Michigan. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT00381641 about?
NCT00381641 is a clinical study titled "Sunitinib Malate in Treating Patients With Thyroid Cancer That Did Not Respond to Iodine I 131 and Cannot Be Removed by Surgery". This phase II trial studies how well sunitinib malate works in treating patients with thyroid cancer that did not respond to iodine I 131 (radioactive iodine) and cannot be removed by surgery. Sunitinib malate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth ...
What is the current status of trial NCT00381641?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 63 participants. The study started on 2006-08-29. Estimated completion is 2024-12-10.
What conditions does trial NCT00381641 study?
This clinical trial studies the following conditions: Recurrent Thyroid Gland Carcinoma, Refractory Thyroid Gland Carcinoma, Differentiated Thyroid Gland Carcinoma, Stage IV Thyroid Gland Follicular Carcinoma AJCC v7, Stage IV Thyroid Gland Papillary Carcinoma AJCC v7. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT00381641?
The interventions under investigation include: Laboratory Biomarker Analysis (OTHER), Sunitinib (DRUG), Pharmacogenomic Study (OTHER), Sunitinib Malate (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT00381641?
This trial is sponsored by National Cancer Institute (NCI), which has 2,390 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT00381641 being conducted?
This trial has 17 study locations across Illinois, Indiana, Maryland, Michigan, Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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