Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT00373880 · ClinicalTrials.gov registry record · Phase 2
Effects of Aripiprazole on Cocaine Craving and Self-Administration
A Phase 2 study of Cocaine Abuse, sponsored by New York State Psychiatric Institute.
- Completed
- Registry status
- Phase 2
- Development phase
- 26
- Enrollment target
- 1
- Study location
NCT00373880: Completed Phase 2 study of Cocaine Abuse, sponsored by New York State Psychiatric Institute.
NCT00373880 is a Phase 2 study of Cocaine Abuse that has completed, run by New York State Psychiatric Institute. The registered enrollment target is 26 participants, below the 916-participant average among 9 other Cocaine Abuse trials with a reported enrollment target (97% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00373880, a Phase 2 study of Cocaine Abuse, has completed, sponsored by New York State Psychiatric Institute.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 26 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of this study is to investigate whether aripiprazole will decrease cocaine self-administration, subjective effects and cravings compared to placebo.
Primary Outcome
Mean number of cocaine choices as a function of cocaine dose and aripiprazole dose (n=8). Participants sampled the dose of cocaine available for the session and then had five choices to respond for money ($5.00) or cocaine using a modified progressive-ratio schedule.
Conditions Studied
Interventions
- DRUG Aripiprazole + Cocaine
- DRUG Placebo + Cocaine
Study Locations (1)
New York
- Irving Center for Clinical Research - New York
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 26 participants |
| Start Date | 2005-04 |
| Est. Completion | 2008-09 |
| Phase | Phase 2 |
What the finished NCT00373880 record still lists
NCT00373880 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 26 participants, a relatively small participant target, below the 916-participant average among 9 other Cocaine Abuse trials with a reported enrollment target (97% lower).
The record links to 1 condition, with Cocaine Abuse appearing as the primary indexed condition, and to 2 interventions - of which Aripiprazole + Cocaine is the first listed.
NCT00373880 reports a single indexed study location in New York.
Frequently Asked Questions
What is clinical trial NCT00373880 about?
NCT00373880 is a clinical study titled "Effects of Aripiprazole on Cocaine Craving and Self-Administration". The purpose of this study is to investigate whether aripiprazole will decrease cocaine self-administration, subjective effects and cravings compared to placebo.
What is the current status of trial NCT00373880?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 26 participants. The study started on 2005-04. Estimated completion is 2008-09.
What conditions does trial NCT00373880 study?
This clinical trial studies the following conditions: Cocaine Abuse.
What interventions are being tested in trial NCT00373880?
The interventions under investigation include: Aripiprazole + Cocaine (DRUG), Placebo + Cocaine (DRUG).
Who is sponsoring clinical trial NCT00373880?
This trial is sponsored by New York State Psychiatric Institute, which has 364 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00373880 being conducted?
This trial has 1 study location across New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Cocaine Abuse
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT00373880's enrollment target sits among peer trials
26 7th of 9 higher than 3 of 9 other Cocaine Abuse trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Cocaine Abuse trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Therapeutic Substance Abuse Treatment in Pregnancy - 1
COMPLETED · Phase 2
-
Substance Abuse Pre-Treatment Screening Study
RECRUITING
-
Progesterone for the Treatment of Cocaine Dependence - 1
COMPLETED · NA
-
Exercise as a Behavioral Treatment for Cocaine Dependence
COMPLETED · NA
-
Study to Assess Potential Interactions Between Intravenous Cocaine and Oral Lorcaserin
COMPLETED · Phase 1
-
CBT With Disulfiram and Contingency Management
COMPLETED · Phase 1
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT02646475 · 26 participants · Phase 1
Metabolic Effects of Angiotensin-(1-7)
- NCT03603223 · 26 participants · Phase 2
Pembrolizumab in Treating Participants With Leukoplakia
- NCT04063592 · 26 participants · NA
AMI Construction in Lower Extremity Residual Limbs
- NCT04906460 · 26 participants · Phase 1
Open-label Study of WVE-N531 in Patients With Duchenne Muscular Dystrophy (FORWARD-53)
Similar registry start date
- NCT05988463 · started 2027-01-01 · Phase 1
Dose-Escalation Study of Artesunate Patients With IPF
- NCT07219706 · started 2026-12-10 · NA
Dietary Fiber and Time Restricted Eating
- NCT02831335 · started 2026-12-01
Technical Development of Multi-Parametric Renocerebral MRI
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia