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NCT00361972 · ClinicalTrials.gov registry record · Phase 2
Elucidation of Acid-Induced Pulmonary Inflammation
A Phase 2 study, sponsored by University of Utah.
- Terminated
- Registry status
- Phase 2
- Development phase
- 17
- Enrollment target
NCT00361972: Clinical Trial Phase 2 study, sponsored by University of Utah.
NCT00361972 is a Phase 2 study that was terminated before completion, run by University of Utah. The registered enrollment target is 17 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (87% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00361972, a Phase 2 study, was terminated before completion, sponsored by University of Utah.
- TERMINATED
- Registry status
- Phase 2
- Development phase
- 17 participants
- Enrollment target
Study Summary
This study will evaluate how heartburn may lead to different types of inflammation in one's airways. Additionally, the study will determine whether aggressive treatment of heartburn results in improvement in both symptoms of heartburn and asthma but also in documented improvement in airway inflammation as determined by biopsy. The results of this study will be important in directing future research into the relationship between heartburn and asthma and may provide a clue whether certain subtypes of asthma may be caused primarily by gastroesophageal reflux (GER).
Primary Outcome
Change in mean lymphocyte count in bronchus intermedius biopsies between lansoprazole and placebo groups, measured in lymphocytes per square millimeter. Overall mean differences were compared (post-intervention mean lymphocyte count minus pre-intervention mean lymphocyte count) between the two intervention groups.
Interventions
- DRUG placebo
- DRUG lansoprazole
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 17 participants |
| Start Date | 2006-08 |
| Est. Completion | 2009-04 |
| Phase | Phase 2 |
Why NCT00361972 stopped before completion
NCT00361972 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 17 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (87% lower).
The record links to 0 conditions, and to 2 interventions - of which placebo is the first listed.
NCT00361972 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00361972 about?
NCT00361972 is a clinical study titled "Elucidation of Acid-Induced Pulmonary Inflammation". This study will evaluate how heartburn may lead to different types of inflammation in one's airways. Additionally, the study will determine whether aggressive treatment of heartburn results in improvement in both symptoms of heartburn and asthma but also in documented improvement in airway inflammat...
What is the current status of trial NCT00361972?
This trial is currently terminated. It is a Phase 2 study. The enrollment target is 17 participants. The study started on 2006-08. Estimated completion is 2009-04.
What interventions are being tested in trial NCT00361972?
The interventions under investigation include: placebo (DRUG), lansoprazole (DRUG).
Who is sponsoring clinical trial NCT00361972?
This trial is sponsored by University of Utah, which has 818 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00361972's enrollment target sits among peer trials
17 1903rd of 2000 higher than 93 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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