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NCT00352911 · ClinicalTrials.gov registry record · Phase 2
Antiviral Activity and Safety of Mifepristone at 2 Doses in HIV-1 Infected Subjects
A Phase 2 study of HIV Infections, sponsored by VGX Pharmaceuticals.
- Completed
- Registry status
- Phase 2
- Development phase
- 19
- Enrollment target
- 3
- Study locations
NCT00352911: Completed Phase 2 study of HIV Infections, sponsored by VGX Pharmaceuticals.
NCT00352911 is a Phase 2 study of HIV Infections that has completed, run by VGX Pharmaceuticals. The registered enrollment target is 19 participants, below the 446-participant average among 542 other HIV Infections trials with a reported enrollment target (96% lower). The trial reports 3 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00352911, a Phase 2 study of HIV Infections, has completed, sponsored by VGX Pharmaceuticals.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 19 participants
- Enrollment target
- 3
- Study locations
Study Summary
The objective of the study is to determine whether mifepristone (VGX-410) has anti-HIV-1 activity at doses of either 300 mg or 600 mg per day after oral administration for 14 days at each dose level.
Primary Outcome
Mean log change in HIV RNA viral load (significant reduction is considered \>0.5 log 10) from baseline (Day 1) to Day 56 following 150mg twice daily for 14 days, dose escalation to 300mg twice daily for 14 days and then 28 days off treatment.
Conditions Studied
Interventions
- DRUG VGX-410 (Mifepristone)
- DRUG Placebo for VGX-410 (Mifepristone)
Study Locations (3)
Pennsylvania
- University of Pennsylvania - Philadelphia
- Veterans Hospital of Philadelphia - Philadelphia
District of Columbia
- Georgetown University - Washington D.C.
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 19 participants |
| Start Date | 2006-07 |
| Est. Completion | 2007-11 |
| Phase | Phase 2 |
What the finished NCT00352911 record still lists
NCT00352911 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 19 participants, a relatively small participant target, below the 446-participant average among 542 other HIV Infections trials with a reported enrollment target (96% lower).
The record links to 1 condition, with HIV Infections appearing as the primary indexed condition, and to 2 interventions - of which VGX-410 (Mifepristone) is the first listed.
NCT00352911 reports a single indexed study location in Pennsylvania, District of Columbia.
Frequently Asked Questions
What is clinical trial NCT00352911 about?
NCT00352911 is a clinical study titled "Antiviral Activity and Safety of Mifepristone at 2 Doses in HIV-1 Infected Subjects". The objective of the study is to determine whether mifepristone (VGX-410) has anti-HIV-1 activity at doses of either 300 mg or 600 mg per day after oral administration for 14 days at each dose level.
What is the current status of trial NCT00352911?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 19 participants. The study started on 2006-07. Estimated completion is 2007-11.
What conditions does trial NCT00352911 study?
This clinical trial studies the following conditions: HIV Infections.
What interventions are being tested in trial NCT00352911?
The interventions under investigation include: VGX-410 (Mifepristone) (DRUG), Placebo for VGX-410 (Mifepristone) (DRUG).
Who is sponsoring clinical trial NCT00352911?
This trial is sponsored by VGX Pharmaceuticals, which has 4 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00352911 being conducted?
This trial has 3 study locations across District of Columbia, Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for HIV Infections
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT00352911's enrollment target sits among peer trials
19 502nd of 542 higher than 40 of 542 other HIV Infections trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other HIV Infections trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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