Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT00347776 · ClinicalTrials.gov registry record · Phase 4
Study of Azithromycin to Prevent Recurrent Trichiasis Following Surgery in Ethiopia
A Phase 4 study, sponsored by Johns Hopkins University.
- Completed
- Registry status
- Phase 4
- Development phase
- 1,452
- Enrollment target
NCT00347776: Completed Phase 4 study, sponsored by Johns Hopkins University.
NCT00347776 is a Phase 4 study that has completed, run by Johns Hopkins University. The registered enrollment target is 1,452 participants, above the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (180% higher). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00347776, a Phase 4 study, has completed, sponsored by Johns Hopkins University.
- COMPLETED
- Registry status
- Phase 4
- Development phase
- 1,452 participants
- Enrollment target
Study Summary
Trachoma, an ocular infection caused by C. trachomatis, is the second leading cause of blindness worldwide.Years of repeated infection with C. trachomatis cause the eyelid to scar and contract and ultimately to rotate inward such that eyelashes rub against the eyeball and abrade the cornea (trichiasis). The World Health Organization (WHO) has endorsed a multi-faceted strategy to combat trachoma, which includes surgery to correct trichiasis. Despite this encouraging news, under the best of circumstances the recurrence rate of trichiasis following surgery is disappointingly high. The objective of our project is to conduct a randomized, controlled clinical trial of post-surgical antibiotic treatment, comparing oral azithromycin to topical tetracycline, for trichiasis surgical patients in Ethiopia with the goal of determining the impact of treatment on rates of trichiasis recurrence at one and two years.
Primary Outcome
Recurrence of trichiasis : Clinical assessment was done by looking for one or more eye lashes touching globe or evidence of epilation.
Interventions
- DRUG azithromycin
- DRUG topical tetracycline
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1,452 participants |
| Start Date | 2001-08 |
| Est. Completion | 2006-12 |
| Phase | Phase 4 |
What the finished NCT00347776 record still lists
NCT00347776 is an interventional study that assigns participants to a tested intervention. Its 1,452 participants enrollment target places it among the larger protocols in the corpus, above the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (180% higher).
The record links to 0 conditions, and to 2 interventions - of which azithromycin is the first listed.
NCT00347776 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00347776 about?
NCT00347776 is a clinical study titled "Study of Azithromycin to Prevent Recurrent Trichiasis Following Surgery in Ethiopia". Trachoma, an ocular infection caused by C. trachomatis, is the second leading cause of blindness worldwide.Years of repeated infection with C. trachomatis cause the eyelid to scar and contract and ultimately to rotate inward such that eyelashes rub against the eyeball and abrade the cornea (trichias...
What is the current status of trial NCT00347776?
This trial is currently completed. It is a Phase 4 study. The enrollment target is 1,452 participants. The study started on 2001-08. Estimated completion is 2006-12.
What interventions are being tested in trial NCT00347776?
The interventions under investigation include: azithromycin (DRUG), topical tetracycline (DRUG).
Who is sponsoring clinical trial NCT00347776?
This trial is sponsored by Johns Hopkins University, which has 1,448 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00347776's enrollment target sits among peer trials
1,452 53rd of 2000 higher than 1,948 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT06782347 · 1,454 participants · NA
Activating SilverSneakers Benefits for Seniors With Osteoarthritis
- NCT04566328 · 1,450 participants · Phase 3
Testing the Use of Combination Therapy in Adult Patients With Newly Diagnosed Multiple Myeloma, the EQUATE Trial
- NCT05229341 · 1,450 participants · NA
Evaluation of DNA Methylation Signatures for the Diagnosis and Management of Thyroid Nodules
- NCT05910268 · 1,450 participants · NA
Peru Decentralized HIV Care
Similar registry start date
- NCT05988463 · started 2027-01-01 · Phase 1
Dose-Escalation Study of Artesunate Patients With IPF
- NCT07219706 · started 2026-12-10 · NA
Dietary Fiber and Time Restricted Eating
- NCT02831335 · started 2026-12-01
Technical Development of Multi-Parametric Renocerebral MRI
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia