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NCT00342264 · ClinicalTrials.gov registry record
A Nested Case-Control Study of Lung Cancer and Diesel Exhaust Among Non-Metal Miners
A clinical trial, sponsored by National Cancer Institute (NCI).
- Completed
- Registry status
- 1,187
- Enrollment target
NCT00342264: Completed study, sponsored by National Cancer Institute (NCI).
NCT00342264 is a clinical trial that has completed, run by National Cancer Institute (NCI). The registered enrollment target is 1,187 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00342264 has completed, sponsored by National Cancer Institute (NCI).
- COMPLETED
- Registry status
- 1,187 participants
- Enrollment target
Study Summary
Diesel exhaust has been classified as a probable carcinogen by the International Agency for Research on Cancer and as a potential carcinogen by the National Institute for Occupational Safety and Health (NIOSH). The carcinogenicity of this pollutant is of concern not only for the one million workers who are exposed occupationally, but also for the general population. Over 30 epidemiologic studies of diesel exhaust exposure have been performed, and the results suggest an increase in lung cancer risk. However, the association is not well defined. Past studies have suffered from the use of crude indicators of exposure, inadequate control of confounding, and/or short follow-up periods, low exposure levels, and small numbers of observations. NCI and NIOSH are collaborating on two related studies of diesel exhaust under the NCI/NIOSH Interagency Agreement. First, a retrospective cohort mortality study of about 8,200 non-metal miners will be performed to investigate lung cancer mortality in relation to quantitative measures of diesel exhaust exposure, and to determine whether there is evidence of elevated mortality from other causes of death among diesel exhaust exposed miners. The retrospective cohort study will be performed using existing records and information and has been exempted from IRB review. NIOSH is the lead agency on the retrospective cohort study. The proposed study is a case-control study nested in the retrospective cohort of non-metal miners. The study is expected to include at least 160 members of the cohort who died from lung cancer and four matched controls for each case. Using a structured questionnaire, detailed information will be collected on each subject's lifetime exposure to diesel exhaust, as well as information on smoking and other confounders. This information will allow investigators to examine the association between lung cancer and different quantitative measures of diesel exhaust exposure, adjusted for smoking and other potential confounde
Primary Outcome
Lung cancer death
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1,187 participants |
| Start Date | 1999-01-12 |
| Est. Completion | 2024-04-16 |
What the finished NCT00342264 record still lists
NCT00342264 is an observational study that tracks outcomes without assigning an intervention. Its 1,187 participants enrollment target places it among the larger protocols in the corpus.
The record links to 0 conditions, and to 0 interventions.
NCT00342264 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00342264 about?
NCT00342264 is a clinical study titled "A Nested Case-Control Study of Lung Cancer and Diesel Exhaust Among Non-Metal Miners". Diesel exhaust has been classified as a probable carcinogen by the International Agency for Research on Cancer and as a potential carcinogen by the National Institute for Occupational Safety and Health (NIOSH). The carcinogenicity of this pollutant is of concern not only for the one million workers ...
What is the current status of trial NCT00342264?
This trial is currently completed. The enrollment target is 1,187 participants. The study started on 1999-01-12. Estimated completion is 2024-04-16.
Who is sponsoring clinical trial NCT00342264?
This trial is sponsored by National Cancer Institute (NCI), which has 3,257 total clinical trials registered on ClinicalTrials.gov.
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