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NCT00341900 · ClinicalTrials.gov registry record
Study of Markers of Cosmic Radiation Exposure and Effect Among Flight Crews
A clinical trial of Frequency of Chromosome Aberrations, sponsored by National Cancer Institute (NCI).
- Completed
- Registry status
- 134
- Enrollment target
- 1
- Study location
NCT00341900 is a study of Frequency of Chromosome Aberrations that has completed, run by National Cancer Institute (NCI). The registered enrollment target is 134 participants. The trial reports 1 study location across 1 state.
The verdict
NCT00341900, a study of Frequency of Chromosome Aberrations, has completed, sponsored by National Cancer Institute (NCI).
- COMPLETED
- Registry status
- 134 participants
- Enrollment target
- 1
- Study location
Study Summary
Ionizing radiation efficiently induces chromosomal aberrations (CA) and several studies of CA have now been conducted among small groups of flight crews. However, most of the studies only evaluated the unstable aberrations that reflect recent exposures, but not long-term cumulative cosmic radiation exposure. Chromosome painting by fluorescence in situ hybridization (FISH) is a widely used and established cytogenetic method for detecting stable aberrations such as translocations. Thus, FISH can be used for estimating chromosomal damage from cumulative radiation exposure. No large studies of flight crews utilizing FISH have been conducted to date. We propose a study to measure CA using FISH in a group of pilots estimated to have high comic radiation exposure based on flight histories, i.e., those with long duration flying international routes, and a comparison group of university faculty with minimal flying history. These measurements will be used to determine if pilots have elevated frequencies of CA (specifically stable translocations) as compared with the university faculty. In addition, the frequencies of CA will be examined in relation to the cumulative cosmic radiation dose to determine if there is a dose-response relationship. Individual cumulative doses will be calculated from pilot flight histories using a computer program developed by the FAA which estimates cosmic radiation does by accounting for changes in altitude and latitude, and the 11-year solar cycle at the time of the flight. We will collect information on age, lifestyle factors, diet, health history, family cancer history, and medical radiation exposures from personal interview and self-administered dietary questionaire. These factors may affect the CA frequency and so we plan to adjust for them in the statistical analyses. Pilots will be identified based on the Allied Pilots Association roster and faculty from a commercial company that maintains a database of university faculty, including those
Conditions Studied
Study Locations (1)
Ohio
- National Institute for Occupational Safety and Health - Cincinnati
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 134 participants |
| Start Date | 2001-11-09 |
| Est. Completion | 2020-04-03 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00341900
The ClinicalTrials.gov registry entry for NCT00341900 describes a study currently listed as completed, categorized as an unspecified phase. The registered enrollment target is 134 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is National Cancer Institute (NCI), which has 3,257 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Frequency of Chromosome Aberrations appearing as the primary indexed condition, and to 0 interventions.
NCT00341900 reports 1 study location spanning 1 distinct geographic area - top geographies include Ohio.
Frequently Asked Questions
What is clinical trial NCT00341900 about?
NCT00341900 is a clinical study titled "Study of Markers of Cosmic Radiation Exposure and Effect Among Flight Crews". Ionizing radiation efficiently induces chromosomal aberrations (CA) and several studies of CA have now been conducted among small groups of flight crews. However, most of the studies only evaluated the unstable aberrations that reflect recent exposures, but not long-term cumulative cosmic radiation ...
What is the current status of trial NCT00341900?
This trial is currently completed. The enrollment target is 134 participants. The study started on 2001-11-09. Estimated completion is 2020-04-03.
What conditions does trial NCT00341900 study?
This clinical trial studies the following conditions: Frequency of Chromosome Aberrations.
Who is sponsoring clinical trial NCT00341900?
This trial is sponsored by National Cancer Institute (NCI), which has 3,257 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00341900 being conducted?
This trial has 1 study location across Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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