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NCT00340535 · ClinicalTrials.gov registry record
Effect of Genetic Differences on Levels of Water Disinfection Byproducts in Blood After Showering
A clinical trial, sponsored by National Cancer Institute (NCI).
- Completed
- Registry status
- 100
- Enrollment target
NCT00340535: Completed study, sponsored by National Cancer Institute (NCI).
NCT00340535 is a clinical trial that has completed, run by National Cancer Institute (NCI). The registered enrollment target is 100 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00340535 has completed, sponsored by National Cancer Institute (NCI).
- COMPLETED
- Registry status
- 100 participants
- Enrollment target
Study Summary
This study will examine whether genetic differences among individuals affect blood levels of certain chemicals called DBPs after showering. Chemicals such as chlorine and ozone are used to kill germs in water. These chemicals may react with organic matter in the water and form other chemicals called disinfection byproducts, or DBPs. Although people are usually exposed to DBPs by drinking tap water, these chemicals may also penetrate the body during showering. This study will see whether the levels of DBPs after showering vary among individuals depending on differences in genes that code for enzymes called GSTT1, CYP2D6, and CYP2E1, which break down DBPs. This study, sponsored by the Centers for Disease Control and Prevention and the National Institutes of Health, is conducted at the University of Pittsburgh's Center for Clinical Pharmacology. Healthy adults between 18 and 45 years of age who do not smoke cigarettes and are not taking any medicines may be eligible for this study. Candidates are screened with a medical history and blood and urine tests. Participants are given a diary to record the foods they eat and how much water they drink during the 2 days before their study appointment. The following activities are scheduled on the appointment day: * Measurements of blood pressure, height, and weight, and pregnancy test for women * Questions about alcohol consumed and medications taken in the last 48 hours * Review of food and water diary * Interview for demographic information (name, address, date of birth, etc.) and other information, such as sex, height, weight. Subjects are also asked about anything, such as exercise, that might affect their breathing, since breathing problems are a rare side effect of chlorzoxazone, a drug used in this study. * Urine sample collection * Blood draw and insertion of a small catheter (plastic tube) to allow for additional blood draws during the test procedure without having repeated needle sticks * 10-minute shower in a privat
Primary Outcome
Levels of triahlomethane levels in the blood
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 100 participants |
| Start Date | 2004-06-23 |
| Est. Completion | 2021-03-04 |
What the finished NCT00340535 record still lists
NCT00340535 is an observational study that tracks outcomes without assigning an intervention. The registered 100 participants enrollment target is mid-sized for trials with a published cap.
The record links to 0 conditions, and to 0 interventions.
NCT00340535 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00340535 about?
NCT00340535 is a clinical study titled "Effect of Genetic Differences on Levels of Water Disinfection Byproducts in Blood After Showering". This study will examine whether genetic differences among individuals affect blood levels of certain chemicals called DBPs after showering. Chemicals such as chlorine and ozone are used to kill germs in water. These chemicals may react with organic matter in the water and form other chemicals called...
What is the current status of trial NCT00340535?
This trial is currently completed. The enrollment target is 100 participants. The study started on 2004-06-23. Estimated completion is 2021-03-04.
Who is sponsoring clinical trial NCT00340535?
This trial is sponsored by National Cancer Institute (NCI), which has 3,257 total clinical trials registered on ClinicalTrials.gov.
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