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NCT00339209 · ClinicalTrials.gov registry record
Prospective Lung Transplant Database for Genetic Research
A clinical trial of Lung Transplantation Rejection, sponsored by National Institute of Environmental Health Sciences (NIEHS).
- Completed
- Registry status
- 400
- Enrollment target
- 2
- Study locations
NCT00339209 is a study of Lung Transplantation Rejection that has completed, run by National Institute of Environmental Health Sciences (NIEHS). The registered enrollment target is 400 participants. The trial reports 2 study locations across 1 state.
The verdict
NCT00339209, a study of Lung Transplantation Rejection, has completed, sponsored by National Institute of Environmental Health Sciences (NIEHS).
- COMPLETED
- Registry status
- 400 participants
- Enrollment target
- 2
- Study locations
Study Summary
This study will create a database of clinical and biological research for use in future studies, with information obtained from lung transplant recipients. The database will consist of genetic material and clinical outcomes to be used in future genotyping studies, that is, studies regarding the genetic makeup of individuals. Lung transplantation has become an important option for patients with advanced lung disease. More than 10,000 patients have received them to date, and about 1,200 transplant operations are performed worldwide each year. Although short-term survival has continued to improve, the 5-year survival rate is less than 50 percent. Most post transplant deaths are directly or directly caused by chronic lung rejection, a condition of scarring that worsens lung function. Patients evaluated for lung transplants at Duke University Medical Center may be eligible for this study. For developing the database, a small amount of blood, about 3 tablespoons, will be collected from patients. Blood collection for the research will be done at the same time as blood is drawn for necessary tests. The blood cells and DNA (which contains genetic material) will be isolated for analysis. Patients' DNA samples collected will be identified by a code, and all other identifying information will be removed. Patients may be asked to donate additional blood samples after their lung transplant if researchers would like to reexamine their blood. This study will not have a direct benefit for participants. However, during the study, if it is found that any patients have an inherited risk for a disease likely to cause early death if the disease is not treated, then the researchers will attempt to notify those patients. Overall, it is hoped that information gained during this study will help medical professionals to learn more about immune activation and to see how the reactivity of lung transplant patients changes over time. If specific genetic risks could be identified, it might lead
Conditions Studied
Study Locations (2)
North Carolina
- Duke University Medical Center - Durham
- NIEHS, Research Triangle Park - Research Triangle Park
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 400 participants |
| Start Date | 2005-06-23 |
| Est. Completion | 2007-04-13 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00339209
The ClinicalTrials.gov registry entry for NCT00339209 describes a study currently listed as completed, categorized as an unspecified phase. The registered enrollment target is 400 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is National Institute of Environmental Health Sciences (NIEHS), which has 145 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Lung Transplantation Rejection appearing as the primary indexed condition, and to 0 interventions.
NCT00339209 reports 2 study locations spanning 1 distinct geographic area - top geographies include North Carolina.
Frequently Asked Questions
What is clinical trial NCT00339209 about?
NCT00339209 is a clinical study titled "Prospective Lung Transplant Database for Genetic Research". This study will create a database of clinical and biological research for use in future studies, with information obtained from lung transplant recipients. The database will consist of genetic material and clinical outcomes to be used in future genotyping studies, that is, studies regarding the gene...
What is the current status of trial NCT00339209?
This trial is currently completed. The enrollment target is 400 participants. The study started on 2005-06-23. Estimated completion is 2007-04-13.
What conditions does trial NCT00339209 study?
This clinical trial studies the following conditions: Lung Transplantation Rejection.
Who is sponsoring clinical trial NCT00339209?
This trial is sponsored by National Institute of Environmental Health Sciences (NIEHS), which has 145 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00339209 being conducted?
This trial has 2 study locations across North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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