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NCT00321204 · ClinicalTrials.gov registry record
A Retrospective Study of the Role of Thiazolidinediones to Reduce the Incidence of Atrial Arrhythmias
A clinical trial, sponsored by Emory University.
- Terminated
- Registry status
- 600
- Enrollment target
NCT00321204: Clinical Trial study, sponsored by Emory University.
NCT00321204 is a clinical trial that was terminated before completion, run by Emory University. The registered enrollment target is 600 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00321204 was terminated before completion, sponsored by Emory University.
- TERMINATED
- Registry status
- 600 participants
- Enrollment target
Study Summary
It is well known that abnormal heart beats from the top parts of the heart, atrial fibrillation (AF) and atrial flutter (Aflut), occur frequently after most types of cardiac surgeries. Postoperative AF and Aflut are associated with significant morbidity, longer hospital stay, and higher related costs. Currently therapies are marginally effective at preventing this abnormal heart beat. The incidence of abnormal heart beats after cardiac surgery seems to be a function of the amount of inflammation and oxidative stress induced. Our group and others have shown that atrial abnormal heart beats are associated with increased oxidative stress. Thiazolidinediones (TZDs) are medications used to treat diabetes. Beside their glucose lowering effects, TZDs are shown to exhibit anti-inflammatory and antioxidant properties. Therefore, we propose to retrospectively analyze the effect of pre-operative TZDs on the incidence of post-operative AF or Aflut. This study will involve retrospective chart reviews without further patient contact of all patients having undergone cardiac surgery in Emory University Hospital, Crawford Long Hospital, or the VA Medical Center from 2000 to 2005. This study is preparatory to a funding proposal for a prospective trial.
Interventions
- PROCEDURE TZD reducing the incidence of atrial arrhythmias
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 600 participants |
| Start Date | 2005-12 |
| Est. Completion | 2007-02 |
Why NCT00321204 stopped before completion
NCT00321204 is an observational study that tracks outcomes without assigning an intervention. The registered 600 participants enrollment target is mid-sized for trials with a published cap.
The record links to 0 conditions, and to 1 intervention - of which TZD reducing the incidence of atrial arrhythmias is the first listed.
NCT00321204 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00321204 about?
NCT00321204 is a clinical study titled "A Retrospective Study of the Role of Thiazolidinediones to Reduce the Incidence of Atrial Arrhythmias". It is well known that abnormal heart beats from the top parts of the heart, atrial fibrillation (AF) and atrial flutter (Aflut), occur frequently after most types of cardiac surgeries. Postoperative AF and Aflut are associated with significant morbidity, longer hospital stay, and higher related cost...
What is the current status of trial NCT00321204?
This trial is currently terminated. The enrollment target is 600 participants. The study started on 2005-12. Estimated completion is 2007-02.
What interventions are being tested in trial NCT00321204?
The interventions under investigation include: TZD reducing the incidence of atrial arrhythmias (PROCEDURE).
Who is sponsoring clinical trial NCT00321204?
This trial is sponsored by Emory University, which has 1,208 total clinical trials registered on ClinicalTrials.gov.
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