Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT00286221 · ClinicalTrials.gov registry record · Phase 2
IVPCA in the Management of Pain Following Major Intracranial Surgery
A Phase 2 study of Intracranial Surgery, sponsored by Johns Hopkins University.
- Completed
- Registry status
- Phase 2
- Development phase
- 159
- Enrollment target
- 1
- Study location
NCT00286221: Completed Phase 2 study of Intracranial Surgery, sponsored by Johns Hopkins University.
NCT00286221 is a Phase 2 study of Intracranial Surgery that has completed, run by Johns Hopkins University. The registered enrollment target is 159 participants, above the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (20% higher). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00286221, a Phase 2 study of Intracranial Surgery, has completed, sponsored by Johns Hopkins University.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 159 participants
- Enrollment target
- 1
- Study location
Study Summary
This is a prospective, randomized controlled clinical trial to evaluate the efficacy and safety of intravenous patient controlled analgesia (IVPCA) in patients following major intracranial surgery (e.g. brain tumors, vascular surgery). We will compare pain, opioid consumption, costs, sedation level, length of hospital stay, patient satisfaction, and complications in patients randomized to receive either pro re nata (PRN) or IVPCA opioids. We hypothesize that IVPCA will be more efficacious than PRN opioids in the treatment of postoperative without an increased incidence of adverse effects.
Primary Outcome
Patients' Numerical Rating Scale scores (0-10: 0 = no pain, 10 = worst imaginable pain)
Conditions Studied
Interventions
- DRUG PCA fentanyl
- DRUG PRN fentanyl
Study Locations (1)
Maryland
- Johns Hopkins Hospital - Baltimore
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 159 participants |
| Start Date | 2006-03 |
| Est. Completion | 2010-07 |
| Phase | Phase 2 |
What the finished NCT00286221 record still lists
NCT00286221 is an interventional study that assigns participants to a tested intervention. The registered 159 participants enrollment target is mid-sized for trials with a published cap, above the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (20% higher).
The record links to 1 condition, with Intracranial Surgery appearing as the primary indexed condition, and to 2 interventions - of which PCA fentanyl is the first listed.
NCT00286221 reports a single indexed study location in Maryland.
Frequently Asked Questions
What is clinical trial NCT00286221 about?
NCT00286221 is a clinical study titled "IVPCA in the Management of Pain Following Major Intracranial Surgery". This is a prospective, randomized controlled clinical trial to evaluate the efficacy and safety of intravenous patient controlled analgesia (IVPCA) in patients following major intracranial surgery (e.g. brain tumors, vascular surgery). We will compare pain, opioid consumption, costs, sedation level,...
What is the current status of trial NCT00286221?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 159 participants. The study started on 2006-03. Estimated completion is 2010-07.
What conditions does trial NCT00286221 study?
This clinical trial studies the following conditions: Intracranial Surgery.
What interventions are being tested in trial NCT00286221?
The interventions under investigation include: PCA fentanyl (DRUG), PRN fentanyl (DRUG).
Who is sponsoring clinical trial NCT00286221?
This trial is sponsored by Johns Hopkins University, which has 1,448 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00286221 being conducted?
This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00286221's enrollment target sits among peer trials
159 442nd of 2000 higher than 1,558 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT05267626 · 159 participants · Phase 1
Study of AU-007, A Monoclonal Antibody That Binds to IL-2 and Inhibits IL-2Rα Binding, in Patients With Unresectable Locally Advanced or Metastatic Cancer
- NCT06321575 · 159 participants · NA
The Golazo® Peripheral Atherectomy System for a Safe and Effective Atherectomy (GREAT Trial)
- NCT06729151 · 159 participants
Effect of Intradetrusor onabotulinumtoxinA Injection Versus Conservative Management on Female Sexual Function in Patients With Bladder Pain Syndrome
- NCT07023731 · 159 participants · Phase 1
A Study to Evaluate ARV-806 in Adults With Advanced Cancer That Has the KRAS G12D Mutation
Similar registry start date
- NCT05988463 · started 2027-01-01 · Phase 1
Dose-Escalation Study of Artesunate Patients With IPF
- NCT07219706 · started 2026-12-10 · NA
Dietary Fiber and Time Restricted Eating
- NCT02831335 · started 2026-12-01
Technical Development of Multi-Parametric Renocerebral MRI
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia