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NCT00230802 · ClinicalTrials.gov registry record · NA
Thyroid Hormone Dose Adjustment in Pregnancy
A NA study, sponsored by Brigham and Women's Hospital.
- Completed
- Registry status
- NA
- Development phase
- 48
- Enrollment target
NCT00230802: Completed NA study, sponsored by Brigham and Women's Hospital.
NCT00230802 is a NA study that has completed, run by Brigham and Women's Hospital. The registered enrollment target is 48 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (97% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00230802, a NA study, has completed, sponsored by Brigham and Women's Hospital.
- COMPLETED
- Registry status
- NA
- Development phase
- 48 participants
- Enrollment target
Study Summary
Our aim is to compare the safety and efficacy of 2 different empiric levothyroxine dose adjustment recommendations to be made at the first confirmation of pregnancy in women with a history of hypothyroidism. Subjects will be women with a prior diagnosis of hypothyroidism who are taking thyroid hormone replacement and who are less than 8 weeks pregnant. Upon confirmation of pregnancy, subjects will be randomized to increase their weekly thyroid hormone dose by either 2 or 3 tablets (28 or 42%). Thyroid function will be evaluated every two weeks in the first 20 weeks and then again at week 30 and post-partum. Primary endpoints will be the proportion of women in each group who remain euthyroid throughout the first trimester and throughout pregnancy.
Primary Outcome
The proportion of patients in each treatment arm euthyroid through gestation
Interventions
- DRUG levothyroxine
- DRUG Anticipatory dose increase of levothyroxine
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 48 participants |
| Start Date | 2005-07 |
| Est. Completion | 2010-07 |
| Phase | NA |
What the finished NCT00230802 record still lists
NCT00230802 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 48 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (97% lower).
The record links to 0 conditions, and to 2 interventions - of which levothyroxine is the first listed.
NCT00230802 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00230802 about?
NCT00230802 is a clinical study titled "Thyroid Hormone Dose Adjustment in Pregnancy". Our aim is to compare the safety and efficacy of 2 different empiric levothyroxine dose adjustment recommendations to be made at the first confirmation of pregnancy in women with a history of hypothyroidism. Subjects will be women with a prior diagnosis of hypothyroidism who are taking thyroid hormo...
What is the current status of trial NCT00230802?
This trial is currently completed. It is a NA study. The enrollment target is 48 participants. The study started on 2005-07. Estimated completion is 2010-07.
What interventions are being tested in trial NCT00230802?
The interventions under investigation include: levothyroxine (DRUG), Anticipatory dose increase of levothyroxine (DRUG).
Who is sponsoring clinical trial NCT00230802?
This trial is sponsored by Brigham and Women's Hospital, which has 937 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00230802's enrollment target sits among peer trials
48 1381st of 2000 higher than 601 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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