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NCT00215228 · ClinicalTrials.gov registry record · Phase 2
Effects of Duloxetine vs. Escitalopram on Heart Rate Variability in Depression
A Phase 2 study, sponsored by Duke University.
- Completed
- Registry status
- Phase 2
- Development phase
- 26
- Enrollment target
NCT00215228 is a Phase 2 study that has completed, run by Duke University. The registered enrollment target is 26 participants.
The verdict
NCT00215228, a Phase 2 study, has completed, sponsored by Duke University.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 26 participants
- Enrollment target
Study Summary
Low heart rate variability is a marker of increased risk of cardiac mortality, and is observed in depressed coronary artery disease patients. Some antidepressants may themselves, however, decrease heart rate variability. We will test the hypothesis that greater reduction in heart rate variability will be associated with duloxetine (which has noradrenergic activity) than escitalopram (a selective serotonin reuptake inhibitor). We will also test the hypothesis that changes in heart rate variability are related to the magnitude of norepinephrine transporter occupancy.
Interventions
- DRUG duloxetine vs. escitalopram
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 26 participants |
| Start Date | 2005-07 |
| Est. Completion | 2007-08 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00215228
The ClinicalTrials.gov registry entry for NCT00215228 describes a study currently listed as completed, categorized as Phase 2. The registered enrollment target is 26 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Duke University, which has 1,725 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which duloxetine vs. escitalopram is the first listed.
NCT00215228 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT00215228 about?
NCT00215228 is a clinical study titled "Effects of Duloxetine vs. Escitalopram on Heart Rate Variability in Depression". Low heart rate variability is a marker of increased risk of cardiac mortality, and is observed in depressed coronary artery disease patients. Some antidepressants may themselves, however, decrease heart rate variability. We will test the hypothesis that greater reduction in heart rate variability wi...
What is the current status of trial NCT00215228?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 26 participants. The study started on 2005-07. Estimated completion is 2007-08.
What interventions are being tested in trial NCT00215228?
The interventions under investigation include: duloxetine vs. escitalopram (DRUG).
Who is sponsoring clinical trial NCT00215228?
This trial is sponsored by Duke University, which has 1,725 total clinical trials registered on ClinicalTrials.gov.
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