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NCT00187226 · ClinicalTrials.gov registry record · Phase 2
A Study for Image-Guided Radiation Therapy in Pediatric Brain Tumors and Side Effects
A Phase 2 study, sponsored by St. Jude Children's Research Hospital.
- Completed
- Registry status
- Phase 2
- Development phase
- 361
- Enrollment target
NCT00187226: Completed Phase 2 study, sponsored by St. Jude Children's Research Hospital.
NCT00187226 is a Phase 2 study that has completed, run by St. Jude Children's Research Hospital. The registered enrollment target is 361 participants, above the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (171% higher). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00187226, a Phase 2 study, has completed, sponsored by St. Jude Children's Research Hospital.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 361 participants
- Enrollment target
Study Summary
The purpose of the study was to determine if treating a limited volume of normal tissue surrounding the tumor or tumor bed using conformal radiation therapy would achieve similar rates of disease control compared to standard radiation therapy. The study was also conducted to examine the effect of irradiation on neurological, endocrine and cognitive function.
Primary Outcome
Local tumor control was determined by Magnetic Resonance Imaging (MRI) of the brain and spine performed after radiation therapy. Imaging studies were performed every 3-4 months during the first three years and then every 6 months through five years. Imaging studies demonstrating tumor progression were electronically registered to the imaging data used to plan therapy. Local failure included tumor progression within the volume that received the prescribed dose of irradiation.
Interventions
- PROCEDURE Radiation Therapy
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 361 participants |
| Start Date | 1997-06 |
| Est. Completion | 2022-02-01 |
| Phase | Phase 2 |
What the finished NCT00187226 record still lists
NCT00187226 is an interventional study that assigns participants to a tested intervention. The registered 361 participants enrollment target is mid-sized for trials with a published cap, above the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (171% higher).
The record links to 0 conditions, and to 1 intervention - of which Radiation Therapy is the first listed.
NCT00187226 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00187226 about?
NCT00187226 is a clinical study titled "A Study for Image-Guided Radiation Therapy in Pediatric Brain Tumors and Side Effects". The purpose of the study was to determine if treating a limited volume of normal tissue surrounding the tumor or tumor bed using conformal radiation therapy would achieve similar rates of disease control compared to standard radiation therapy. The study was also conducted to examine the effect of ir...
What is the current status of trial NCT00187226?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 361 participants. The study started on 1997-06. Estimated completion is 2022-02-01.
What interventions are being tested in trial NCT00187226?
The interventions under investigation include: Radiation Therapy (PROCEDURE).
Who is sponsoring clinical trial NCT00187226?
This trial is sponsored by St. Jude Children's Research Hospital, which has 410 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00187226's enrollment target sits among peer trials
361 123rd of 2000 higher than 1,878 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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