Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT00186914 · ClinicalTrials.gov registry record · Phase 1
Stromal Therapy of Osteodysplasia After Allogeneic Bone Marrow Transplantation
A Phase 1 study of Osteodysplasia, sponsored by St. Jude Children's Research Hospital.
- Completed
- Registry status
- Phase 1
- Development phase
- 8
- Enrollment target
- 1
- Study location
NCT00186914 is a Phase 1 study of Osteodysplasia that has completed, run by St. Jude Children's Research Hospital. The registered enrollment target is 8 participants. The trial reports 1 study location across 1 state.
The verdict
NCT00186914, a Phase 1 study of Osteodysplasia, has completed, sponsored by St. Jude Children's Research Hospital.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 8 participants
- Enrollment target
- 1
- Study location
Study Summary
Osteodysplasia or poorly formed bones, "brittle bones" is a genetic disease with no known proven treatments. Some forms of osteodysplasia may cause severe disability and even death. Eligible patients were limited to those children with Osteodysplasia who had undergone a previous allogeneic bone marrow transplant at St. Jude. The study intervention involved an infusion of a specified number of ex vivo expanded stromal cells obtained from the bone marrow of the same donor from whom they received their primary transplant procedure. These bone marrow stromal cells can become bone-forming cells, called osteoblasts. Participants then received 2 infusions of ex vivo expanded, gene marked cells not less than 6 months after bone marrow transplantation. The second cell infusion occurred between 14 to 21 days after the first infusion in the absence of toxicity. The goal of the study was to evaluate the safety and toxicity of these infusions.
Conditions Studied
Interventions
- BIOLOGICAL Marrow stromal cell infusion
Study Locations (1)
Tennessee
- St. Jude Children's Research Hospital - Memphis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 8 participants |
| Start Date | 1999-07 |
| Est. Completion | 2008-01 |
| Phase | Phase 1 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00186914
The ClinicalTrials.gov registry entry for NCT00186914 describes a study currently listed as completed, categorized as Phase 1. The registered enrollment target is 8 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is St. Jude Children's Research Hospital, which has 410 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Osteodysplasia appearing as the primary indexed condition, and to 1 intervention - of which Marrow stromal cell infusion is the first listed.
NCT00186914 reports 1 study location spanning 1 distinct geographic area - top geographies include Tennessee.
Frequently Asked Questions
What is clinical trial NCT00186914 about?
NCT00186914 is a clinical study titled "Stromal Therapy of Osteodysplasia After Allogeneic Bone Marrow Transplantation". Osteodysplasia or poorly formed bones, "brittle bones" is a genetic disease with no known proven treatments. Some forms of osteodysplasia may cause severe disability and even death. Eligible patients were limited to those children with Osteodysplasia who had undergone a previous allogeneic bone mar...
What is the current status of trial NCT00186914?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 8 participants. The study started on 1999-07. Estimated completion is 2008-01.
What conditions does trial NCT00186914 study?
This clinical trial studies the following conditions: Osteodysplasia.
What interventions are being tested in trial NCT00186914?
The interventions under investigation include: Marrow stromal cell infusion (BIOLOGICAL).
Who is sponsoring clinical trial NCT00186914?
This trial is sponsored by St. Jude Children's Research Hospital, which has 410 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00186914 being conducted?
This trial has 1 study location across Tennessee. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.