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NCT00186914 · ClinicalTrials.gov registry record · Phase 1
Stromal Therapy of Osteodysplasia After Allogeneic Bone Marrow Transplantation
A Phase 1 study of Osteodysplasia, sponsored by St. Jude Children's Research Hospital.
- Completed
- Registry status
- Phase 1
- Development phase
- 8
- Enrollment target
- 1
- Study location
NCT00186914: Completed Phase 1 study of Osteodysplasia, sponsored by St. Jude Children's Research Hospital.
NCT00186914 is a Phase 1 study of Osteodysplasia that has completed, run by St. Jude Children's Research Hospital. The registered enrollment target is 8 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (87% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00186914, a Phase 1 study of Osteodysplasia, has completed, sponsored by St. Jude Children's Research Hospital.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 8 participants
- Enrollment target
- 1
- Study location
Study Summary
Osteodysplasia or poorly formed bones, "brittle bones" is a genetic disease with no known proven treatments. Some forms of osteodysplasia may cause severe disability and even death. Eligible patients were limited to those children with Osteodysplasia who had undergone a previous allogeneic bone marrow transplant at St. Jude. The study intervention involved an infusion of a specified number of ex vivo expanded stromal cells obtained from the bone marrow of the same donor from whom they received their primary transplant procedure. These bone marrow stromal cells can become bone-forming cells, called osteoblasts. Participants then received 2 infusions of ex vivo expanded, gene marked cells not less than 6 months after bone marrow transplantation. The second cell infusion occurred between 14 to 21 days after the first infusion in the absence of toxicity. The goal of the study was to evaluate the safety and toxicity of these infusions.
Conditions Studied
Interventions
- BIOLOGICAL Marrow stromal cell infusion
Study Locations (1)
Tennessee
- St. Jude Children's Research Hospital - Memphis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 8 participants |
| Start Date | 1999-07 |
| Est. Completion | 2008-01 |
| Phase | Phase 1 |
What the finished NCT00186914 record still lists
NCT00186914 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 8 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (87% lower).
The record links to 1 condition, with Osteodysplasia appearing as the primary indexed condition, and to 1 intervention - of which Marrow stromal cell infusion is the first listed.
NCT00186914 reports a single indexed study location in Tennessee.
Frequently Asked Questions
What is clinical trial NCT00186914 about?
NCT00186914 is a clinical study titled "Stromal Therapy of Osteodysplasia After Allogeneic Bone Marrow Transplantation". Osteodysplasia or poorly formed bones, "brittle bones" is a genetic disease with no known proven treatments. Some forms of osteodysplasia may cause severe disability and even death. Eligible patients were limited to those children with Osteodysplasia who had undergone a previous allogeneic bone mar...
What is the current status of trial NCT00186914?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 8 participants. The study started on 1999-07. Estimated completion is 2008-01.
What conditions does trial NCT00186914 study?
This clinical trial studies the following conditions: Osteodysplasia.
What interventions are being tested in trial NCT00186914?
The interventions under investigation include: Marrow stromal cell infusion (BIOLOGICAL).
Who is sponsoring clinical trial NCT00186914?
This trial is sponsored by St. Jude Children's Research Hospital, which has 410 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00186914 being conducted?
This trial has 1 study location across Tennessee. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00186914's enrollment target sits among peer trials
8 1959th of 2000 higher than 29 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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