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NCT00186810 · ClinicalTrials.gov registry record · Phase 2
Stem Cell Transplantation With Identical Donors for Patients With Sickle Cell Disease
A Phase 2 study, sponsored by St. Jude Children's Research Hospital.
- Completed
- Registry status
- Phase 2
- Development phase
- 15
- Enrollment target
NCT00186810 is a Phase 2 study that has completed, run by St. Jude Children's Research Hospital. The registered enrollment target is 15 participants.
The verdict
NCT00186810, a Phase 2 study, has completed, sponsored by St. Jude Children's Research Hospital.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 15 participants
- Enrollment target
Study Summary
This protocol studied the effect of administration of a myeloablative pretransplant preparative regimen followed by an infusion of donor stem cells in children with severe sickle cell disease. The donor graft consisted of bone marrow or cord blood derived from a genetically matched sibling. The primary aim of the study was to evaluate how well the donated cells migrated to the bone marrow and begin producing healthy red blood cells, white blood cells and platelets (engrafted), how well the recipients immune system recovered, and assess any regimen related toxicities including a potentially life-threatening transplant related complication called graft-versus-host-disease or GVHD.
Interventions
- PROCEDURE Allogeneic stem cell transplant
- DRUG Busulfan, Cyclophosphamide, Horse ATG
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 15 participants |
| Start Date | 1992-12 |
| Est. Completion | 2007-10 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00186810
The ClinicalTrials.gov registry entry for NCT00186810 describes a study currently listed as completed, categorized as Phase 2. The registered enrollment target is 15 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is St. Jude Children's Research Hospital, which has 410 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 2 interventions - of which Allogeneic stem cell transplant is the first listed.
NCT00186810 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT00186810 about?
NCT00186810 is a clinical study titled "Stem Cell Transplantation With Identical Donors for Patients With Sickle Cell Disease". This protocol studied the effect of administration of a myeloablative pretransplant preparative regimen followed by an infusion of donor stem cells in children with severe sickle cell disease. The donor graft consisted of bone marrow or cord blood derived from a genetically matched sibling. The pri...
What is the current status of trial NCT00186810?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 15 participants. The study started on 1992-12. Estimated completion is 2007-10.
What interventions are being tested in trial NCT00186810?
The interventions under investigation include: Allogeneic stem cell transplant (PROCEDURE), Busulfan, Cyclophosphamide, Horse ATG (DRUG).
Who is sponsoring clinical trial NCT00186810?
This trial is sponsored by St. Jude Children's Research Hospital, which has 410 total clinical trials registered on ClinicalTrials.gov.
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