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NCT00186810 · ClinicalTrials.gov registry record · Phase 2
Stem Cell Transplantation With Identical Donors for Patients With Sickle Cell Disease
A Phase 2 study, sponsored by St. Jude Children's Research Hospital.
- Completed
- Registry status
- Phase 2
- Development phase
- 15
- Enrollment target
NCT00186810: Completed Phase 2 study, sponsored by St. Jude Children's Research Hospital.
NCT00186810 is a Phase 2 study that has completed, run by St. Jude Children's Research Hospital. The registered enrollment target is 15 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (89% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00186810, a Phase 2 study, has completed, sponsored by St. Jude Children's Research Hospital.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 15 participants
- Enrollment target
Study Summary
This protocol studied the effect of administration of a myeloablative pretransplant preparative regimen followed by an infusion of donor stem cells in children with severe sickle cell disease. The donor graft consisted of bone marrow or cord blood derived from a genetically matched sibling. The primary aim of the study was to evaluate how well the donated cells migrated to the bone marrow and begin producing healthy red blood cells, white blood cells and platelets (engrafted), how well the recipients immune system recovered, and assess any regimen related toxicities including a potentially life-threatening transplant related complication called graft-versus-host-disease or GVHD.
Interventions
- PROCEDURE Allogeneic stem cell transplant
- DRUG Busulfan, Cyclophosphamide, Horse ATG
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 15 participants |
| Start Date | 1992-12 |
| Est. Completion | 2007-10 |
| Phase | Phase 2 |
What the finished NCT00186810 record still lists
NCT00186810 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 15 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (89% lower).
The record links to 0 conditions, and to 2 interventions - of which Allogeneic stem cell transplant is the first listed.
NCT00186810 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00186810 about?
NCT00186810 is a clinical study titled "Stem Cell Transplantation With Identical Donors for Patients With Sickle Cell Disease". This protocol studied the effect of administration of a myeloablative pretransplant preparative regimen followed by an infusion of donor stem cells in children with severe sickle cell disease. The donor graft consisted of bone marrow or cord blood derived from a genetically matched sibling. The pri...
What is the current status of trial NCT00186810?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 15 participants. The study started on 1992-12. Estimated completion is 2007-10.
What interventions are being tested in trial NCT00186810?
The interventions under investigation include: Allogeneic stem cell transplant (PROCEDURE), Busulfan, Cyclophosphamide, Horse ATG (DRUG).
Who is sponsoring clinical trial NCT00186810?
This trial is sponsored by St. Jude Children's Research Hospital, which has 410 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00186810's enrollment target sits among peer trials
15 1919th of 2000 higher than 60 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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