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NCT00145587 · ClinicalTrials.gov registry record · NA
Stem Cell Transplantation for Children Affected With Osteopetrosis
A NA study, sponsored by St. Jude Children's Research Hospital.
- Terminated
- Registry status
- NA
- Development phase
- 15
- Enrollment target
NCT00145587 is a NA study that was terminated before completion, run by St. Jude Children's Research Hospital. The registered enrollment target is 15 participants.
The verdict
NCT00145587, a NA study, was terminated before completion, sponsored by St. Jude Children's Research Hospital.
- TERMINATED
- Registry status
- NA
- Development phase
- 15 participants
- Enrollment target
Study Summary
Malignant infantile osteopetrosis (MIOP) is a rare fatal genetic disorder that is characterized by the bone's inability to regulate remodeling. The only curative therapy is hematopoietic stem cell transplantation. Stem cells provided from an HLA identical matched sibling donor is the standard of care, but not feasible for the majority of patients. In addition, due to the potentially rapid progression of this disease, the time to identify a suitable HLA matched unrelated donor is not optimal. Therefore this study is designed to test the hypothesis that children with osteopetrosis can properly engraft hematopoietic stem cells that are donated from a partially matched parental donor, or "haploidentical" stem cell donor that are processed on the investigational device, CliniMACS selection system.
Interventions
- PROCEDURE Stem Cell Transplantation
- DEVICE Miltenyi Biotec CliniMACS
- DRUG Systemic chemotherapy and antibodies
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 15 participants |
| Start Date | 2004-07 |
| Est. Completion | 2009-02 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00145587
The ClinicalTrials.gov registry entry for NCT00145587 describes a study currently listed as terminated, categorized as NA. The registered enrollment target is 15 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is St. Jude Children's Research Hospital, which has 410 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 3 interventions - of which Stem Cell Transplantation is the first listed.
NCT00145587 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT00145587 about?
NCT00145587 is a clinical study titled "Stem Cell Transplantation for Children Affected With Osteopetrosis". Malignant infantile osteopetrosis (MIOP) is a rare fatal genetic disorder that is characterized by the bone's inability to regulate remodeling. The only curative therapy is hematopoietic stem cell transplantation. Stem cells provided from an HLA identical matched sibling donor is the standard of car...
What is the current status of trial NCT00145587?
This trial is currently terminated. It is a NA study. The enrollment target is 15 participants. The study started on 2004-07. Estimated completion is 2009-02.
What interventions are being tested in trial NCT00145587?
The interventions under investigation include: Stem Cell Transplantation (PROCEDURE), Miltenyi Biotec CliniMACS (DEVICE), Systemic chemotherapy and antibodies (DRUG).
Who is sponsoring clinical trial NCT00145587?
This trial is sponsored by St. Jude Children's Research Hospital, which has 410 total clinical trials registered on ClinicalTrials.gov.
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