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NCT00123123 · ClinicalTrials.gov registry record · Phase 2
Effect of Improved Oral Hygiene to Prevent Pneumonia in Hospitalized Patients
A Phase 2 study of Pneumonia, sponsored by State University of New York at Buffalo.
- Completed
- Registry status
- Phase 2
- Development phase
- 175
- Enrollment target
- 1
- Study location
NCT00123123: Completed Phase 2 study of Pneumonia, sponsored by State University of New York at Buffalo.
NCT00123123 is a Phase 2 study of Pneumonia that has completed, run by State University of New York at Buffalo. The registered enrollment target is 175 participants, below the 4,516-participant average among 47 other Pneumonia trials with a reported enrollment target (96% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00123123, a Phase 2 study of Pneumonia, has completed, sponsored by State University of New York at Buffalo.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 175 participants
- Enrollment target
- 1
- Study location
Study Summary
Recent studies have found that poor oral hygiene may foster the colonization of the oropharynx by potential respiratory pathogens in mechanically-ventilated (MV), intensive care unit (ICU) patients. Thus, improvements in oral hygiene in MV-ICU patients may prevent ventilator-associated pneumonia (VAP). The specific aims of this investigation are: 1) to organize the necessary infrastructure to develop and perform a pilot clinical trial to evaluate alternative oral hygiene procedures to prevent VAP; 2) to use this organization to perform a pilot clinical trial to determine if the use of oral topical chlorhexidine gluconate (CHX) will prevent dental plaque, oropharyngeal colonization by respiratory pathogens, and VAP in MV-ICU patients.
Primary Outcome
Samples were diluted and plated on sheep's blood agar (to isolate S. aureus), and MacConkey agar (for isolation of Gram-negative bacilli) and incubated for 72 hours at 37°C in 5% carbon dioxide. Plates were assessed for growth for the following target bacteria: S. aureus, P. aeruginosa, Acinetobacter species, and enteric organisms (Klebsiella pneumoniae, Serratia marcescens, Enterobacter species, Proteus mirabilis, Escherichia coli). Results of quantitative cultures were expressed as colony form
Conditions Studied
Interventions
- DRUG placebo
- DRUG chlorhexidine gluconate oral rinse (0.12%)
Study Locations (1)
New York
- University of Buffalo, The State University of New York - Buffalo
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 175 participants |
| Start Date | 2004-03 |
| Est. Completion | 2007-11 |
| Phase | Phase 2 |
What the finished NCT00123123 record still lists
NCT00123123 is an interventional study that assigns participants to a tested intervention. The registered 175 participants enrollment target is mid-sized for trials with a published cap, below the 4,516-participant average among 47 other Pneumonia trials with a reported enrollment target (96% lower).
The record links to 1 condition, with Pneumonia appearing as the primary indexed condition, and to 2 interventions - of which placebo is the first listed.
NCT00123123 reports a single indexed study location in New York.
Frequently Asked Questions
What is clinical trial NCT00123123 about?
NCT00123123 is a clinical study titled "Effect of Improved Oral Hygiene to Prevent Pneumonia in Hospitalized Patients". Recent studies have found that poor oral hygiene may foster the colonization of the oropharynx by potential respiratory pathogens in mechanically-ventilated (MV), intensive care unit (ICU) patients. Thus, improvements in oral hygiene in MV-ICU patients may prevent ventilator-associated pneumonia (VA...
What is the current status of trial NCT00123123?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 175 participants. The study started on 2004-03. Estimated completion is 2007-11.
What conditions does trial NCT00123123 study?
This clinical trial studies the following conditions: Pneumonia.
What interventions are being tested in trial NCT00123123?
The interventions under investigation include: placebo (DRUG), chlorhexidine gluconate oral rinse (0.12%) (DRUG).
Who is sponsoring clinical trial NCT00123123?
This trial is sponsored by State University of New York at Buffalo, which has 243 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00123123 being conducted?
This trial has 1 study location across New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Pneumonia
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT00123123's enrollment target sits among peer trials
175 23rd of 47 higher than 25 of 47 other Pneumonia trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Pneumonia trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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