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NCT00106249 · ClinicalTrials.gov registry record · Phase 2
Transcranial Magnetic Stimulation (TMS) and Obsessive Compulsive Disorder (OCD)
A Phase 2 study, sponsored by New York State Psychiatric Institute.
- Completed
- Registry status
- Phase 2
- Development phase
- 27
- Enrollment target
NCT00106249 is a Phase 2 study that has completed, run by New York State Psychiatric Institute. The registered enrollment target is 27 participants.
The verdict
NCT00106249, a Phase 2 study, has completed, sponsored by New York State Psychiatric Institute.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 27 participants
- Enrollment target
Study Summary
This study will evaluate the clinical efficacy of functional Magnetic Resonance Imaging (fMRI) guided 1 Hz repetitive Transcranial Magnetic Stimulation (rTMS) applied to the Supplementary Motor Area (SMA) in OCD patients who have not fully responded to conventional therapies. The investigators will collect TMS measures of motor cortex excitability to test whether rTMS restores normal levels of intracortical inhibition found to be deficient in OCD. The investigators hypothesize that: 1. Compared to sham (placebo), active rTMS will improve symptoms of OCD as assessed with the Yale Brown Obsessive Compulsive Scale (Y-BOCS) and Clinical Global Impression (CGI). 2. Active (but not sham) rTMS will normalize levels of motor cortex excitability, as reflected by increased intracortical inhibition, motor threshold, and cortical silent period, and by decreased intracortical facilitation, relative to pre-treatment baseline.
Interventions
- DEVICE Repetitive Transcranial Magnetic Stimulation (rTMS)
- DEVICE Sham
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 27 participants |
| Start Date | 2004-11 |
| Est. Completion | 2014-01 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00106249
The ClinicalTrials.gov registry entry for NCT00106249 describes a study currently listed as completed, categorized as Phase 2. The registered enrollment target is 27 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is New York State Psychiatric Institute, which has 364 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 2 interventions - of which Repetitive Transcranial Magnetic Stimulation (rTMS) is the first listed.
NCT00106249 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT00106249 about?
NCT00106249 is a clinical study titled "Transcranial Magnetic Stimulation (TMS) and Obsessive Compulsive Disorder (OCD)". This study will evaluate the clinical efficacy of functional Magnetic Resonance Imaging (fMRI) guided 1 Hz repetitive Transcranial Magnetic Stimulation (rTMS) applied to the Supplementary Motor Area (SMA) in OCD patients who have not fully responded to conventional therapies. The investigators will ...
What is the current status of trial NCT00106249?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 27 participants. The study started on 2004-11. Estimated completion is 2014-01.
What interventions are being tested in trial NCT00106249?
The interventions under investigation include: Repetitive Transcranial Magnetic Stimulation (rTMS) (DEVICE), Sham (DEVICE).
Who is sponsoring clinical trial NCT00106249?
This trial is sponsored by New York State Psychiatric Institute, which has 364 total clinical trials registered on ClinicalTrials.gov.
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