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NCT00074334 · ClinicalTrials.gov registry record · Phase 1
TP-38 Toxin in Treating Young Patients With Recurrent or Progressive Supratentorial High-Grade Glioma
A Phase 1 study, sponsored by Pediatric Brain Tumor Consortium.
- Terminated
- Registry status
- Phase 1
- Development phase
- 3
- Enrollment target
NCT00074334: Clinical Trial Phase 1 study, sponsored by Pediatric Brain Tumor Consortium.
NCT00074334 is a Phase 1 study that was terminated before completion, run by Pediatric Brain Tumor Consortium. The registered enrollment target is 3 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (95% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00074334, a Phase 1 study, was terminated before completion, sponsored by Pediatric Brain Tumor Consortium.
- TERMINATED
- Registry status
- Phase 1
- Development phase
- 3 participants
- Enrollment target
Study Summary
RATIONALE: The TP-38 toxin can locate tumor cells and kill them without harming normal cells. Giving TP-38 toxin directly into the tumor may kill more tumor cells. PURPOSE: This phase I/II trial is studying the side effects and best dose of TP-38 toxin administered directly into the brain and to see how well it works in treating young patients with recurrent or progressive supratentorial high-grade glioma.
Interventions
- PROCEDURE conventional surgery
- BIOLOGICAL TGFa-PE38 immunotoxin
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 3 participants |
| Start Date | 2004-05 |
| Est. Completion | 2006-06 |
| Phase | Phase 1 |
Why NCT00074334 stopped before completion
NCT00074334 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 3 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (95% lower).
The record links to 0 conditions, and to 2 interventions - of which conventional surgery is the first listed.
NCT00074334 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00074334 about?
NCT00074334 is a clinical study titled "TP-38 Toxin in Treating Young Patients With Recurrent or Progressive Supratentorial High-Grade Glioma". RATIONALE: The TP-38 toxin can locate tumor cells and kill them without harming normal cells. Giving TP-38 toxin directly into the tumor may kill more tumor cells. PURPOSE: This phase I/II trial is studying the side effects and best dose of TP-38 toxin administered directly into the brain and to se...
What is the current status of trial NCT00074334?
This trial is currently terminated. It is a Phase 1 study. The enrollment target is 3 participants. The study started on 2004-05. Estimated completion is 2006-06.
What interventions are being tested in trial NCT00074334?
The interventions under investigation include: conventional surgery (PROCEDURE), TGFa-PE38 immunotoxin (BIOLOGICAL).
Who is sponsoring clinical trial NCT00074334?
This trial is sponsored by Pediatric Brain Tumor Consortium, which has 27 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00074334's enrollment target sits among peer trials
3 1999th of 2000 higher than 1 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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