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NCT00067275 · ClinicalTrials.gov registry record
The Effect of Dopamine on Motor Skills Training
A clinical trial of Cerebrovascular Accident, sponsored by National Institute of Neurological Disorders and Stroke (NINDS).
- Completed
- Registry status
- 98
- Enrollment target
- 1
- Study location
NCT00067275: Completed study of Cerebrovascular Accident, sponsored by National Institute of Neurological Disorders and Stroke (NINDS).
NCT00067275 is a study of Cerebrovascular Accident that has completed, run by National Institute of Neurological Disorders and Stroke (NINDS). The registered enrollment target is 98 participants, below the 514-participant average among 26 other Cerebrovascular Accident trials with a reported enrollment target (81% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00067275, a study of Cerebrovascular Accident, has completed, sponsored by National Institute of Neurological Disorders and Stroke (NINDS).
- COMPLETED
- Registry status
- 98 participants
- Enrollment target
- 1
- Study location
Study Summary
This study will examine how dopamine, a brain chemical, affects motor training. Taken by mouth, dopamine can enhance motor training, especially during rehabilitation after brain damage. The study will also examine whether Sinemet, a drug containing a precursor of dopamine, can improve motor training. Healthy normal volunteers and stroke patients between 18 and 80 years of age may be eligible for this study. Healthy volunteers must be right-handed. Stroke patients must have had a stroke that caused weakness in one hand, from which they have recovered enough to be able to move the thumb in different directions. Participants will have up to three study sessions, as follows: Prestudy 1 (MRI, TMS with motor training) * Session 1: Magnetic resonance imaging (MRI) of the brain. This procedure uses a strong magnetic field and radio waves to show structural and chemical changes in tissues. During the scan, the patient lies on a table in a narrow cylinder containing a magnetic field. He or she can communicate with the staff administering the test at all times. * Session 2: Transcranial magnetic stimulation (TMS) - The subject sits in a comfortable chair with the right forearm held still at the side and the head held still by an aluminum frame. A magnetic coil is placed over the head, and a small probe is attached to the thumb to measure thumb movement. Magnetic pulses are occasionally delivered over the scalp, likely inducing a mild thumb movement. After this test, the subject takes a tablet of either Sinemet or placebo (a look-alike pill with no active ingredient). Fifty minutes after taking the pill, the subject undergoes motor training that involves performing brisk thumb movements at a rate of 1 movement per second. At the end of the training, TMS is repeated. * Session 3: Identical to session 2, except subjects who took Sinemet in session 2 now take placebo, and vice versa. Prestudy 2 (MRI, PET without motor training, no TMS) * Session 1: MRI of the brain if the sub
Conditions Studied
Study Locations (1)
Maryland
- National Institutes of Health Clinical Center, 9000 Rockville Pike - Bethesda
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 98 participants |
| Start Date | 2003-08-08 |
| Est. Completion | 2007-08-15 |
What the finished NCT00067275 record still lists
NCT00067275 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 98 participants, a relatively small participant target, below the 514-participant average among 26 other Cerebrovascular Accident trials with a reported enrollment target (81% lower).
The record links to 1 condition, with Cerebrovascular Accident appearing as the primary indexed condition, and to 0 interventions.
NCT00067275 reports a single indexed study location in Maryland.
Frequently Asked Questions
What is clinical trial NCT00067275 about?
NCT00067275 is a clinical study titled "The Effect of Dopamine on Motor Skills Training". This study will examine how dopamine, a brain chemical, affects motor training. Taken by mouth, dopamine can enhance motor training, especially during rehabilitation after brain damage. The study will also examine whether Sinemet, a drug containing a precursor of dopamine, can improve motor training...
What is the current status of trial NCT00067275?
This trial is currently completed. The enrollment target is 98 participants. The study started on 2003-08-08. Estimated completion is 2007-08-15.
What conditions does trial NCT00067275 study?
This clinical trial studies the following conditions: Cerebrovascular Accident.
Who is sponsoring clinical trial NCT00067275?
This trial is sponsored by National Institute of Neurological Disorders and Stroke (NINDS), which has 567 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00067275 being conducted?
This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT00067275's enrollment target sits among peer trials
98 12th of 26 higher than 15 of 26 other Cerebrovascular Accident trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Cerebrovascular Accident trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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