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NCT00045721 · ClinicalTrials.gov registry record · Phase 1
Carmustine Implants and O(6)-Benzylguanine in Treating Children With Recurrent Malignant Glioma
A Phase 1 study, sponsored by Pediatric Brain Tumor Consortium.
- Terminated
- Registry status
- Phase 1
- Development phase
- 3
- Enrollment target
NCT00045721: Clinical Trial Phase 1 study, sponsored by Pediatric Brain Tumor Consortium.
NCT00045721 is a Phase 1 study that was terminated before completion, run by Pediatric Brain Tumor Consortium. The registered enrollment target is 3 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (95% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00045721, a Phase 1 study, was terminated before completion, sponsored by Pediatric Brain Tumor Consortium.
- TERMINATED
- Registry status
- Phase 1
- Development phase
- 3 participants
- Enrollment target
Study Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Chemotherapy placed into the surrounding tissue after surgery to remove the tumor may kill any remaining tumor cells. O(6)-benzylguanine may increase the effectiveness of carmustine by making tumor cells more sensitive to the drug. PURPOSE: Phase I trial to study the safety of combining O(6)-benzylguanine with carmustine implants in treating children who have recurrent malignant glioma.
Interventions
- DRUG O6-benzylguanine
- PROCEDURE conventional surgery
- PROCEDURE adjuvant therapy
- PROCEDURE neoadjuvant therapy
- DRUG polifeprosan 20 with carmustine implant
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 3 participants |
| Start Date | 2003-03 |
| Est. Completion | 2004-07 |
| Phase | Phase 1 |
Why NCT00045721 stopped before completion
NCT00045721 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 3 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (95% lower).
The record links to 0 conditions, and to 5 interventions - of which O6-benzylguanine is the first listed.
NCT00045721 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00045721 about?
NCT00045721 is a clinical study titled "Carmustine Implants and O(6)-Benzylguanine in Treating Children With Recurrent Malignant Glioma". RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Chemotherapy placed into the surrounding tissue after surgery to remove the tumor may kill any remaining tumor cells. O(6)-benzylguanine may increase the effectiveness of carmustin...
What is the current status of trial NCT00045721?
This trial is currently terminated. It is a Phase 1 study. The enrollment target is 3 participants. The study started on 2003-03. Estimated completion is 2004-07.
What interventions are being tested in trial NCT00045721?
The interventions under investigation include: O6-benzylguanine (DRUG), conventional surgery (PROCEDURE), adjuvant therapy (PROCEDURE), neoadjuvant therapy (PROCEDURE), polifeprosan 20 with carmustine implant (DRUG).
Who is sponsoring clinical trial NCT00045721?
This trial is sponsored by Pediatric Brain Tumor Consortium, which has 27 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00045721's enrollment target sits among peer trials
3 1999th of 2000 higher than 1 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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