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NCT00044369 · ClinicalTrials.gov registry record
Role of the Toxic Metal Cadmium in the Mechanism Producing Infertility With a Varicocele
A clinical trial, sponsored by National Institute of Environmental Health Sciences (NIEHS).
- Completed
- Registry status
- 400
- Enrollment target
NCT00044369: Completed study, sponsored by National Institute of Environmental Health Sciences (NIEHS).
NCT00044369 is a clinical trial that has completed, run by National Institute of Environmental Health Sciences (NIEHS). The registered enrollment target is 400 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00044369 has completed, sponsored by National Institute of Environmental Health Sciences (NIEHS).
- COMPLETED
- Registry status
- 400 participants
- Enrollment target
Study Summary
Varicose veins in the scrotum (varicocele) are responsible for \>20% of male infertility in the US. Varicocele are associated with decreased sperm number and markedly reduced sperm fertilizing ability. Surgical repair or removal of varicocele restores fertility in only 1/3 of cases. The goal of this study is to identify markers that predict the outcome of variocele correction. This would offer considerable health cost savings. Based on preliminary findings, we will obtain testis biopsies and semen specimens from infertile men with varicocele and prospectively examining the levels of cadmium, a toxic metal, and expression of genes required for normal sperm function. The semen and biopsies will be obtained during clinically dictated procedures. Cadmium and gene expression will be compared with response to varicocele repair (i.e., increased sperm production; pregnancy).
Interventions
- PROCEDURE Varicocele repair
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 400 participants |
| Start Date | 2000-05 |
| Est. Completion | 2005-04 |
What the finished NCT00044369 record still lists
NCT00044369 is an observational study that tracks outcomes without assigning an intervention. The registered 400 participants enrollment target is mid-sized for trials with a published cap.
The record links to 0 conditions, and to 1 intervention - of which Varicocele repair is the first listed.
NCT00044369 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00044369 about?
NCT00044369 is a clinical study titled "Role of the Toxic Metal Cadmium in the Mechanism Producing Infertility With a Varicocele". Varicose veins in the scrotum (varicocele) are responsible for \>20% of male infertility in the US. Varicocele are associated with decreased sperm number and markedly reduced sperm fertilizing ability. Surgical repair or removal of varicocele restores fertility in only 1/3 of cases. The goal of this...
What is the current status of trial NCT00044369?
This trial is currently completed. The enrollment target is 400 participants. The study started on 2000-05. Estimated completion is 2005-04.
What interventions are being tested in trial NCT00044369?
The interventions under investigation include: Varicocele repair (PROCEDURE).
Who is sponsoring clinical trial NCT00044369?
This trial is sponsored by National Institute of Environmental Health Sciences (NIEHS), which has 145 total clinical trials registered on ClinicalTrials.gov.
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