Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT00006398 · ClinicalTrials.gov registry record · Phase 3
Prevention of Esophageal Varices by Beta-Adrenergic Blockers
A Phase 3 study of Liver Cirrhosis and Portal Hypertension, sponsored by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).
- Completed
- Registry status
- Phase 3
- Development phase
- 213
- Enrollment target
- 5
- Study locations
NCT00006398: Completed Phase 3 study of Liver Cirrhosis and Portal Hypertension, sponsored by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).
NCT00006398 is a Phase 3 study of Liver Cirrhosis and Portal Hypertension that has completed, run by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). The registered enrollment target is 213 participants, below the 991-participant average among 15 other Liver Cirrhosis trials with a reported enrollment target (79% lower). The trial reports 5 study locations across 4 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00006398, a Phase 3 study of Liver Cirrhosis and Portal Hypertension, has completed, sponsored by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).
- COMPLETED
- Registry status
- Phase 3
- Development phase
- 213 participants
- Enrollment target
- 5
- Study locations
Study Summary
The purpose of this study is to learn whether timolol is useful in preventing or delaying the appearance of gastroesophageal varices, a complication that may develop in the future as a consequence of liver disease. Cirrhosis causes an increased resistance of blood flowing through the liver. This leads to an increased pressure in the portal vein (the vein that takes blood to your liver). High portal pressure is responsible for the appearance of complications of chronic liver disease such as varices and variceal bleeding (bleeding from veins in your esophagus). Timolol belongs to a group of medications called beta-blockers. Beta-blockers decrease high portal pressure and previous studies have shown that beta-blocker pills are useful in preventing bleeding from varices in patients who already have varices. A more desirable effect would be if these pills could prevent not only bleeding from varices but the appearance of varices (and therefore of bleeding).
Primary Outcome
Development of varices
Conditions Studied
Interventions
- DRUG Placebo
- DRUG Timolol Maleate
Study Locations (5)
Connecticut
- Yale University Sch. of Medicine - New Haven
- VA CT Healthcare System - West Haven
Massachusetts
- The Faulkner Hospital - Boston
Catalonia
- Hospital Clinic I Provincial de Barcelona - Barcelona
London
- Royal Free Hospital - Hampstead
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 213 participants |
| Start Date | 1993-08 |
| Est. Completion | 2002-09 |
| Phase | Phase 3 |
What the finished NCT00006398 record still lists
NCT00006398 is an interventional study that assigns participants to a tested intervention. The registered 213 participants enrollment target is mid-sized for trials with a published cap, below the 991-participant average among 15 other Liver Cirrhosis trials with a reported enrollment target (79% lower).
The record links to 3 conditions, with Liver Cirrhosis appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.
NCT00006398 lists 5 locations in 4 states (Connecticut, Massachusetts, Catalonia).
Frequently Asked Questions
What is clinical trial NCT00006398 about?
NCT00006398 is a clinical study titled "Prevention of Esophageal Varices by Beta-Adrenergic Blockers". The purpose of this study is to learn whether timolol is useful in preventing or delaying the appearance of gastroesophageal varices, a complication that may develop in the future as a consequence of liver disease. Cirrhosis causes an increased resistance of blood flowing through the liver. This lea...
What is the current status of trial NCT00006398?
This trial is currently completed. It is a Phase 3 study. The enrollment target is 213 participants. The study started on 1993-08. Estimated completion is 2002-09.
What conditions does trial NCT00006398 study?
This clinical trial studies the following conditions: Liver Cirrhosis, Portal Hypertension, Esophageal and Gastric Varices.
What interventions are being tested in trial NCT00006398?
The interventions under investigation include: Placebo (DRUG), Timolol Maleate (DRUG).
Who is sponsoring clinical trial NCT00006398?
This trial is sponsored by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), which has 490 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00006398 being conducted?
This trial has 5 study locations across Connecticut, Massachusetts, Catalonia, London. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Liver Cirrhosis
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT00006398's enrollment target sits among peer trials
213 8th of 15 higher than 8 of 15 other Liver Cirrhosis trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Liver Cirrhosis trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Cirrhotic Ascites Treatment With Satavaptan in Patients With Ascites Due to Cirrhosis of the Liver (CATS)
COMPLETED · Phase 3
-
National Liver Cancer Screening Trial
RECRUITING · Phase 4
-
Multi-analyte Blood Test Clinical Trial
RECRUITING
-
HepHospital: A Pilot Trial of a Hepatology Home Hospital Intervention for Patients With Advanced Liver Disease
RECRUITING · NA
-
Value of [68Ga]Ga-PSMA-11 PET/MRI in the Assessment of Liver Cirrhosis
RECRUITING
-
A Study to Test Whether BI 3802876 is Tolerated in People With Compensated Liver Cirrhosis Due to Metabolic Dysfunction- Associated Steatohepatitis (MASH)
RECRUITING · Phase 2
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT06476886 · 213 participants · NA
Intensive Crisis Intervention
- NCT06544655 · 213 participants · Phase 1
A Study of BMS-986484 Alone and Combination Therapy in Participants With Advanced Solid Tumors
- NCT07186816 · 213 participants · NA
SUpport From PEeRs to Expand Access Study - Community
- NCT04030507 · 214 participants · NA
Screening Magnetic Resonance Imaging of the Brain in Patients With Breast Cancer
Similar registry start date
- NCT05988463 · started 2027-01-01 · Phase 1
Dose-Escalation Study of Artesunate Patients With IPF
- NCT07219706 · started 2026-12-10 · NA
Dietary Fiber and Time Restricted Eating
- NCT02831335 · started 2026-12-01
Technical Development of Multi-Parametric Renocerebral MRI
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia