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NCT00005576 · ClinicalTrials.gov registry record · Phase 1
Monoclonal Antibody Therapy With Sargramostim and Interleukin-2 in Treating Children With Neuroblastoma
A Phase 1 study of Recurrent Neuroblastoma and Regional Neuroblastoma, sponsored by National Cancer Institute (NCI).
- Completed
- Registry status
- Phase 1
- Development phase
- 6
- Enrollment target
- 1
- Study location
NCT00005576: Completed Phase 1 study of Recurrent Neuroblastoma and Regional Neuroblastoma, sponsored by National Cancer Institute (NCI).
NCT00005576 is a Phase 1 study of Recurrent Neuroblastoma and Regional Neuroblastoma that has completed, run by National Cancer Institute (NCI). The registered enrollment target is 6 participants, below the 1,139-participant average among 9 other Recurrent Neuroblastoma trials with a reported enrollment target (99% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00005576, a Phase 1 study of Recurrent Neuroblastoma and Regional Neuroblastoma, has completed, sponsored by National Cancer Institute (NCI).
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 6 participants
- Enrollment target
- 1
- Study location
Study Summary
Monoclonal antibodies can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells. Colony-stimulating factors such as sargramostim may increase the number of immune cells found in bone marrow or peripheral blood. Interleukin-2 may stimulate a person's white blood cells to kill cancer cells. Combining monoclonal antibody therapy with sargramostim or interleukin-2 may kill more tumor cells. Phase I trial to study the effectiveness of monoclonal antibody therapy given with sargramostim and interleukin-2 in treating children with neuroblastoma who have just completed bone marrow or peripheral stem cell transplantation
Conditions Studied
Interventions
- BIOLOGICAL aldesleukin
- BIOLOGICAL sargramostim
- BIOLOGICAL monoclonal antibody Ch14.18
- DRUG isotretinoin
Study Locations (1)
California
- Children's Oncology Group - Arcadia
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 6 participants |
| Start Date | 2001-01 |
| Phase | Phase 1 |
What the finished NCT00005576 record still lists
NCT00005576 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 6 participants, a relatively small participant target, below the 1,139-participant average among 9 other Recurrent Neuroblastoma trials with a reported enrollment target (99% lower).
The record links to 3 conditions, with Recurrent Neuroblastoma appearing as the primary indexed condition, and to 4 interventions - of which aldesleukin is the first listed.
NCT00005576 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT00005576 about?
NCT00005576 is a clinical study titled "Monoclonal Antibody Therapy With Sargramostim and Interleukin-2 in Treating Children With Neuroblastoma". Monoclonal antibodies can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells. Colony-stimulating factors such as sargramostim may increase the number of immune cells found in bone marrow or peripheral blood. Interleukin-2 may stimulate a ...
What is the current status of trial NCT00005576?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 6 participants. The study started on 2001-01.
What conditions does trial NCT00005576 study?
This clinical trial studies the following conditions: Recurrent Neuroblastoma, Regional Neuroblastoma, Disseminated Neuroblastoma.
What interventions are being tested in trial NCT00005576?
The interventions under investigation include: aldesleukin (BIOLOGICAL), sargramostim (BIOLOGICAL), monoclonal antibody Ch14.18 (BIOLOGICAL), isotretinoin (DRUG).
Who is sponsoring clinical trial NCT00005576?
This trial is sponsored by National Cancer Institute (NCI), which has 3,257 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00005576 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Recurrent Neuroblastoma
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT00005576's enrollment target sits among peer trials
6 9th of 9 higher than 1 of 9 other Recurrent Neuroblastoma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Recurrent Neuroblastoma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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