Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

COMPLETED Phase 1

Radiation Therapy, Paclitaxel, and Cisplatin in Treating Patients With Cancer of the Cervix

NCT00003377 · View on ClinicalTrials.gov ↗

Study Summary

RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Paclitaxel and cisplatin may increase the effectiveness of radiation therapy by making the tumor cells more sensitive to the radiation. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining radiation therapy with chemotherapy may kill more tumor cells. PURPOSE: This phase I/II trial is studying the side effects and best dose of paclitaxel when given with radiation therapy and cisplatin and to see how well they work in treating patients with cancer of the cervix that has spread to the lymph nodes in the pelvis and abdomen.

Conditions Studied

Interventions

  • DRUG cisplatin
  • DRUG paclitaxel
  • RADIATION radiation therapy
  • RADIATION brachytherapy

Study Locations (13)

Ohio

  • MetroHealth's Cancer Care Center at MetroHealth Medical Center — Cleveland
  • Cleveland Clinic Cancer Center at Fairview Hospital — Cleveland
  • Cleveland Clinic Taussig Cancer Center — Cleveland
  • Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University — Columbus
  • Riverside Methodist Hospital Cancer Care — Columbus

Oklahoma

  • Oklahoma University Medical Center — Oklahoma City
  • Cancer Care Associates - Midtown Tulsa — Tulsa

Florida

  • University of Miami Sylvester Comprehensive Cancer Center — Miami

Illinois

  • University of Chicago Cancer Research Center — Chicago

Iowa

  • Holden Comprehensive Cancer Center at University of Iowa — Iowa City

New Jersey

  • Cancer Institute of New Jersey at the Cooper University Hospital - Voorhees — Camden

North Carolina

  • Comprehensive Cancer Center at Wake Forest University — Winston-Salem

Pennsylvania

  • Abramson Cancer Center of the University of Pennsylvania — Philadelphia

Trial Details

FieldValue
Enrollment Target 29 participants
Start Date 1999-11
Est. Completion 2009-07
Phase Phase 1

Sponsor

Gynecologic Oncology Group

61 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT00003377

The ClinicalTrials.gov registry entry for NCT00003377 describes a study currently listed as completed. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 29 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Gynecologic Oncology Group, which has 61 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Cervical Cancer appearing as the primary indexed condition, and to 4 interventions — of which cisplatin is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT00003377 reports 13 study locations spanning 8 distinct geographic areas — top geographies include Ohio, Oklahoma, Florida. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT00003377 about?

NCT00003377 is a clinical study titled "Radiation Therapy, Paclitaxel, and Cisplatin in Treating Patients With Cancer of the Cervix". RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Paclitaxel and cisplatin may increase the effectiveness of radiation therapy by making the tumor cells more sensitive to the radiation. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they ...

What is the current status of trial NCT00003377?

This trial is currently completed. It is a Phase 1 study. The enrollment target is 29 participants. The study started on 1999-11. Estimated completion is 2009-07.

What conditions does trial NCT00003377 study?

This clinical trial studies the following conditions: Cervical Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT00003377?

The interventions under investigation include: cisplatin (DRUG), paclitaxel (DRUG), radiation therapy (RADIATION), brachytherapy (RADIATION). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT00003377?

This trial is sponsored by Gynecologic Oncology Group, which has 61 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT00003377 being conducted?

This trial has 13 study locations across Florida, Illinois, Iowa, New Jersey, North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial