Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

COMPLETED Phase 1

Combination Chemotherapy Plus PSC 833 Followed by Interleukin-2 in Treating Patients With Acute Myelogenous Leukemia

NCT00002925 · View on ClinicalTrials.gov ↗

Study Summary

RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Some cancers may become resistant to chemotherapy drugs. Combining PSC 833 with chemotherapy may reduce resistance to the drugs and allow the cancer cells to be killed. Interleukin-2 may stimulate a person's white blood cells to kill leukemia cells. PURPOSE: Phase I/II trial to study the effectiveness of combination chemotherapy plus PSC 833 followed by additional chemotherapy or peripheral stem cell transplantation and interleukin-2 in treating patients with untreated acute myelogenous leukemia.

Conditions Studied

Interventions

  • DRUG Etoposide
  • DRUG Daunorubicin
  • BIOLOGICAL Aldesleukin
  • DRUG ara-C
  • DRUG PSC-833

Study Locations (20)

New York

  • Roswell Park Cancer Institute — Buffalo
  • CCOP - North Shore University Hospital — Manhasset
  • North Shore University Hospital — Manhasset
  • Memorial Sloan-Kettering Cancer Center — New York

California

  • University of California San Diego Cancer Center — La Jolla
  • UCSF Cancer Center and Cancer Research Institute — San Francisco

Illinois

  • University of Illinois at Chicago Health Sciences Center — Chicago
  • University of Chicago Cancer Research Center — Chicago

Massachusetts

  • Dana-Farber Cancer Institute — Boston
  • University of Massachusetts Memorial Medical Center — Worcester

Missouri

  • Ellis Fischel Cancer Center - Columbia — Columbia
  • Barnes-Jewish Hospital — St Louis

Delaware

  • CCOP - Christiana Care Health Services — Wilmington

District of Columbia

  • Walter Reed Army Medical Center — Washington D.C.

Florida

  • CCOP - Mount Sinai Medical Center — Miami Beach

Trial Details

FieldValue
Enrollment Target 410 participants
Start Date 1997-02
Est. Completion 2010-06
Phase Phase 1

Sponsor

National Cancer Institute (NCI)

2,390 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT00002925

The ClinicalTrials.gov registry entry for NCT00002925 describes a study currently listed as completed. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 410 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is National Cancer Institute (NCI), which has 2,390 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Leukemia appearing as the primary indexed condition, and to 5 interventions — of which Etoposide is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT00002925 reports 20 study locations spanning 13 distinct geographic areas — top geographies include New York, California, Illinois. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT00002925 about?

NCT00002925 is a clinical study titled "Combination Chemotherapy Plus PSC 833 Followed by Interleukin-2 in Treating Patients With Acute Myelogenous Leukemia". RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Some cancers may become resistant to chemotherapy drugs. Combining PSC 833 with chemotherapy may reduce resistance to the drugs and allow the cancer cells to be killed. Interleuki...

What is the current status of trial NCT00002925?

This trial is currently completed. It is a Phase 1 study. The enrollment target is 410 participants. The study started on 1997-02. Estimated completion is 2010-06.

What conditions does trial NCT00002925 study?

This clinical trial studies the following conditions: Leukemia. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT00002925?

The interventions under investigation include: Etoposide (DRUG), Daunorubicin (DRUG), Aldesleukin (BIOLOGICAL), ara-C (DRUG), PSC-833 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT00002925?

This trial is sponsored by National Cancer Institute (NCI), which has 2,390 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT00002925 being conducted?

This trial has 20 study locations across California, Delaware, District of Columbia, Florida, Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial