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NCT00002796 · ClinicalTrials.gov registry record · Phase 1
Phase I-II Study of Fluorouracil in Combination With Phenylbutyrate in Advanced Colorectal Cancer
A Phase 1 study, sponsored by National Cancer Institute (NCI).
- Terminated
- Registry status
- Phase 1
- Development phase
- 46
- Enrollment target
NCT00002796: Clinical Trial Phase 1 study, sponsored by National Cancer Institute (NCI).
NCT00002796 is a Phase 1 study that was terminated before completion, run by National Cancer Institute (NCI). The registered enrollment target is 46 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (23% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00002796, a Phase 1 study, was terminated before completion, sponsored by National Cancer Institute (NCI).
- TERMINATED
- Registry status
- Phase 1
- Development phase
- 46 participants
- Enrollment target
Study Summary
Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Interferon-gamma may interfere with the growth of tumor cells and slow the growth of the tumor. Combining more than one drug with interferon-gamma may kill more tumor cells. This phase I/II trial is studying the side effects and best dose of giving fluorouracil together with phenylbutyrate, indomethacin, and interferon-gamma and to see how well it works in treating patients with stage IV colorectal cancer
Interventions
- DRUG fluorouracil
- BIOLOGICAL recombinant interferon gamma
- DRUG indomethacin
- DRUG sodium phenylbutyrate
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 46 participants |
| Start Date | 1997-05 |
| Phase | Phase 1 |
Why NCT00002796 stopped before completion
NCT00002796 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 46 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (23% lower).
The record links to 0 conditions, and to 4 interventions - of which fluorouracil is the first listed.
NCT00002796 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00002796 about?
NCT00002796 is a clinical study titled "Phase I-II Study of Fluorouracil in Combination With Phenylbutyrate in Advanced Colorectal Cancer". Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Interferon-gamma may interfere with the growth of tumor cells and slow the growth of the tumor. Combining more than one drug with interferon-gamma may kill more tumor cells. This phase I/II t...
What is the current status of trial NCT00002796?
This trial is currently terminated. It is a Phase 1 study. The enrollment target is 46 participants. The study started on 1997-05.
What interventions are being tested in trial NCT00002796?
The interventions under investigation include: fluorouracil (DRUG), recombinant interferon gamma (BIOLOGICAL), indomethacin (DRUG), sodium phenylbutyrate (DRUG).
Who is sponsoring clinical trial NCT00002796?
This trial is sponsored by National Cancer Institute (NCI), which has 3,257 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00002796's enrollment target sits among peer trials
46 1058th of 2000 higher than 935 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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