Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT00002631 · ClinicalTrials.gov registry record · Phase 3
Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Cancer of the Esophagus
A Phase 3 study, sponsored by Radiation Therapy Oncology Group.
- Completed
- Registry status
- Phase 3
- Development phase
- 298
- Enrollment target
NCT00002631: Completed Phase 3 study, sponsored by Radiation Therapy Oncology Group.
NCT00002631 is a Phase 3 study that has completed, run by Radiation Therapy Oncology Group. The registered enrollment target is 298 participants, below the 772-participant average among 15,282 other Phase 3 trials with a reported enrollment target (61% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00002631, a Phase 3 study, has completed, sponsored by Radiation Therapy Oncology Group.
- COMPLETED
- Registry status
- Phase 3
- Development phase
- 298 participants
- Enrollment target
Study Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. It is not known whether high-dose radiation therapy is more effective than standard dose radiation therapy in treating cancer of the esophagus. PURPOSE: Randomized phase III trial to compare the effectiveness of combination chemotherapy plus high- or standard-dose radiation therapy in treating patients with cancer of the esophagus.
Interventions
- DRUG cisplatin
- DRUG fluorouracil
- DRUG chemotherapy
- RADIATION low-LET electron therapy
- RADIATION low-LET photon therapy
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 298 participants |
| Start Date | 1995-06 |
| Phase | Phase 3 |
What the finished NCT00002631 record still lists
NCT00002631 is an interventional study that assigns participants to a tested intervention. The registered 298 participants enrollment target is mid-sized for trials with a published cap, below the 772-participant average among 15,282 other Phase 3 trials with a reported enrollment target (61% lower).
The record links to 0 conditions, and to 5 interventions - of which cisplatin is the first listed.
NCT00002631 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00002631 about?
NCT00002631 is a clinical study titled "Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Cancer of the Esophagus". RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. It is not known whether high-dose radiation therapy is more effective than standard dose radiation therapy in treat...
What is the current status of trial NCT00002631?
This trial is currently completed. It is a Phase 3 study. The enrollment target is 298 participants. The study started on 1995-06.
What interventions are being tested in trial NCT00002631?
The interventions under investigation include: cisplatin (DRUG), fluorouracil (DRUG), chemotherapy (DRUG), low-LET electron therapy (RADIATION), low-LET photon therapy (RADIATION).
Who is sponsoring clinical trial NCT00002631?
This trial is sponsored by Radiation Therapy Oncology Group, which has 144 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00002631's enrollment target sits among peer trials
298 1162nd of 2000 higher than 838 of 2,000 other Phase 3 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 3 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT06305624 · 298 participants · NA
Implementation of Mobile-based Programs for Alcohol Cessation in Treatment of Alcohol-associated Liver Disease
- NCT06754215 · 298 participants · NA
Smoking Cessation Intervention Development for Homeless Youth
- NCT06780111 · 298 participants · Phase 1
Substudy 06E: Umbrella Study of Combination Therapies in Esophageal Cancer (MK-3475-06E/KEYMAKER-U06)
- NCT07209358 · 298 participants · NA
EDX110 Randomized Control Trial for Treatment of DFUs
Similar registry start date
- NCT05988463 · started 2027-01-01 · Phase 1
Dose-Escalation Study of Artesunate Patients With IPF
- NCT07219706 · started 2026-12-10 · NA
Dietary Fiber and Time Restricted Eating
- NCT02831335 · started 2026-12-01
Technical Development of Multi-Parametric Renocerebral MRI
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia