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NCT00001701 · ClinicalTrials.gov registry record
Evaluation of the Association of Polymorphisms in the Innate Immune System With the Risk for Cryptococcus Neoformans Infection in Patients Not Infected With HIV and Complications Associated With Cryptococcus Neoformans Infection
A clinical trial, sponsored by National Cancer Institute (NCI).
- Completed
- Registry status
- 300
- Enrollment target
NCT00001701: Completed study, sponsored by National Cancer Institute (NCI).
NCT00001701 is a clinical trial that has completed, run by National Cancer Institute (NCI). The registered enrollment target is 300 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00001701 has completed, sponsored by National Cancer Institute (NCI).
- COMPLETED
- Registry status
- 300 participants
- Enrollment target
Study Summary
Innate immunity plays an important role for fungal recognition and initiation of fungicidal activity. We hypothesize that subtle differences in different molecules of innate immunity may contribute to either the predisposition or clinical course of infection with Cryptococcus neoformans. To test this hypothesis, we propose to analyze the allelic frequencies of 15 different genes (mannose binding lectin, Fc-gamma receptor IIa and IIb, Fc-gamma receptors IIIa and IIIb, myeloperoxidase, tumor necrosis factor-alpha and -beta, interleukin 1A and 1B, interleukin-1 receptor antagonist, interleukin-10, NRAMP-1, chitotriosidase, and chemokine receptor 5) and their intragenic polymorphic forms and to compare this data to the incidence and severity of C neoformans infection. With this study we hope to identify a group of molecules of innate immunity which influence the risk and severity of invasive C neoformans infection.
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 300 participants |
| Start Date | 1998-07-29 |
What the finished NCT00001701 record still lists
NCT00001701 is an observational study that tracks outcomes without assigning an intervention. The registered 300 participants enrollment target is mid-sized for trials with a published cap.
The record links to 0 conditions, and to 0 interventions.
NCT00001701 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00001701 about?
NCT00001701 is a clinical study titled "Evaluation of the Association of Polymorphisms in the Innate Immune System With the Risk for Cryptococcus Neoformans Infection in Patients Not Infected With HIV and Complications Associated With Cryptococcus Neoformans Infection". Innate immunity plays an important role for fungal recognition and initiation of fungicidal activity. We hypothesize that subtle differences in different molecules of innate immunity may contribute to either the predisposition or clinical course of infection with Cryptococcus neoformans. To test thi...
What is the current status of trial NCT00001701?
This trial is currently completed. The enrollment target is 300 participants. The study started on 1998-07-29.
Who is sponsoring clinical trial NCT00001701?
This trial is sponsored by National Cancer Institute (NCI), which has 3,257 total clinical trials registered on ClinicalTrials.gov.
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